Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients

Gholamhossein Hassanshahi; Seyed Ebrahim Alavi; Hossein Khorramdelazad; Zahra Ahmadi; Ali Fattahi Bagghi; Seyed Hossein Abdollahi; Hasan Ebrahimi Shahmabadi

doi:10.1007/s12639-020-01290-w

Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients

Gholamhossein Hassanshahi, Seyed Ebrahim Alavi, Hossein Khorramdelazad, Zahra Ahmadi, Ali Fattahi Bagghi, Seyed Hossein Abdollahi, Hasan Ebrahimi Shahmabadi

Western Sydney University

Research output: Contribution to journal › Article › peer-review

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Abstract

The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites.

Original language	English
Pages (from-to)	153-158
Number of pages	6
Journal	Journal of Parasitic Diseases
Volume	45
Issue number	1
DOIs	https://doi.org/10.1007/s12639-020-01290-w
Publication status	Published - Mar 2021

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Publisher Copyright:
© 2020, Indian Society for Parasitology.

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title = "Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients",

abstract = "The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites.",

author = "Gholamhossein Hassanshahi and Alavi, {Seyed Ebrahim} and Hossein Khorramdelazad and Zahra Ahmadi and Bagghi, {Ali Fattahi} and Abdollahi, {Seyed Hossein} and Shahmabadi, {Hasan Ebrahimi}",

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doi = "10.1007/s12639-020-01290-w",

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T1 - Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients

AU - Hassanshahi, Gholamhossein

AU - Alavi, Seyed Ebrahim

AU - Khorramdelazad, Hossein

AU - Ahmadi, Zahra

AU - Bagghi, Ali Fattahi

AU - Abdollahi, Seyed Hossein

AU - Shahmabadi, Hasan Ebrahimi

PY - 2021/3

Y1 - 2021/3

N2 - The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites.

AB - The crucial functions of chemokine/receptors in numerous parasitic infections, including leishmaniasis, are well documented. This study aimed to assess the serum levels of CC ligand (CCL) 2, CCL5, and CCL11 in cutaneous leishmaniasis (CL) patients. 64 patients, suffering from CL and 100 healthy people were selected, and their blood serum concentrations of CCL2, CCL5, and CCL11 were measured using enzyme-linked immunosorbent assay. The results demonstrated that while the mean serum levels of CCL5 and CCL11 increased significantly in CL patients, the mean serum levels of CCL2 decreased, compared to the control group. Despite the sufficient production of CCL5 and CCL11 in CL patients, they suffered from CCL2 deficiency, as the defense mechanism against parasitic infection. These findings suggest a mechanism that might partially explain the patients' susceptibility to persistent infection and their inability to clear the parasites.

UR - http://hdl.handle.net/1959.7/uws:61209

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DO - 10.1007/s12639-020-01290-w

M3 - Article

SN - 0971-7196

VL - 45

SP - 153

EP - 158

JO - Journal of Parasitic Diseases

JF - Journal of Parasitic Diseases

IS - 1

ER -

Serum levels of CC chemokine ligands in cutaneous leishmaniasis patients

Abstract

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