Serum methylarginines and spirometry-measured lung function in older adults

Mark A. McEvoy, Peter W. Schofield, Wayne T. Smith, Kingsley Agho, Arduino A. Mangoni, Roy L. Soiza, Roseanne Peel, Stephen J. Hancock, Ciriaco Carru, Angelo Zinellu, John R. Attia

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    6 Citations (Scopus)

    Abstract

    Rationale:Methylarginines are endogenous nitric oxide synthase inhibitors that have been implicated in animal models of lung disease but have not previously been examined for their association with spirometric measures of lung function in humans.Objectives:This study measured serum concentrations of asymmetric and symmetric dimethylarginine in a representative sample of older community-dwelling adults and determined their association with spirometric lung function measures.Methods:Data on clinical, lifestyle, and demographic characteristics, methylated arginines, and L-arginine (measured using LC-MS/MS) were collected from a population-based sample of older Australian adults from the Hunter Community Study. The five key lung function measures included as outcomes were Forced Expiratory Volume in 1 second, Forced Vital Capacity, Forced Expiratory Volume in 1 second to Forced Vital Capacity ratio, Percent Predicted Forced Expiratory Volume in 1 second, and Percent Predicted Forced Vital Capacity.Measurements and Main Results:In adjusted analyses there were statistically significant independent associations between a) higher asymmetric dimethylarginine, lower Forced Expiratory Volume in 1 second and lower Forced Vital Capacity; and b) lower L-arginine/asymmetric dimethylarginine ratio, lower Forced Expiratory Volume in 1 second, lower Percent Predicted Forced Expiratory Volume in 1 second and lower Percent Predicted Forced Vital Capacity. By contrast, no significant associations were observed between symmetric dimethylarginine and lung function.Conclusions:After adjusting for clinical, demographic, biochemical, and pharmacological confounders, higher serum asymmetric dimethylarginine was independently associated with a reduction in key measures of lung function. Further research is needed to determine if methylarginines predict the decline in lung function.
    Original languageEnglish
    Article numbere58390
    Pages (from-to)1-11
    Number of pages11
    JournalPLoS One
    Volume8
    Issue number5
    DOIs
    Publication statusPublished - 2013

    Open Access - Access Right Statement

    Copyright: 2013 McEvoy et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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