Serum podocalyxin for early detection of preeclampsia at 11–13 weeks of gestation

M. Mansilla, Y. Wang, J. Hyett, Silva da, G. Nie

Research output: Contribution to journalArticlepeer-review

Abstract

Podocalyxin is expressed on endothelial surface throughout the body and is likely released into the circulation during pregnancy in association with vessel remodeling. We have recently reported that serum podocalyxin is significantly increased in preeclampsia at disease presentation. In this study we investigated whether serum podocalyxin is altered prior to clinical presentation of preeclampsia. At 11–13 weeks of gestation, serum podocalyxin was significantly elevated in women who subsequently developed preeclampsia. Multi-factorial analysis suggests that combination of serum podocalyxin with the long isoform of HtrA3 and mean arterial pressure, may provide effective detection of late-onset preeclampsia at 11–13 weeks of pregnancy. © 2018 Elsevier Ltd
Original languageEnglish
Pages (from-to)13-15
Number of pages3
JournalPlacenta
Volume71
DOIs
Publication statusPublished - 2018

Fingerprint

Dive into the research topics of 'Serum podocalyxin for early detection of preeclampsia at 11–13 weeks of gestation'. Together they form a unique fingerprint.

Cite this