Abstract
This study explores the possibility that the more favourable clinical prognosis in females with schizophrenia may be associated with their greater network interconnectedness, which is possibly reflected in enhanced "Gamma" (40 Hz) electrical brain activity. An auditory "oddball" task was administered to 35 patients with schizophrenia and 35 age and sex matched controls (25 males and 10 females). Peak Gamma amplitude (from a time series of Gamma activity averaged for 40 target stimuli, as well as the immediately preceding 40 background tones) was examined across 19 sites. Peak Gamma activity occurred 250 to 450 ms in targets and 350 to 550 ms in backgrounds. Multiple within and between group MANOVAs were undertaken analysing both Peak Gamma amplitude (microvolts) and latency (milliseconds). Within-group, the control males showed a pattern of earlier Gamma latency in the right compared with the left hemisphere (F(1, 33)=3.70, p
| Original language | English |
|---|---|
| Pages (from-to) | 131-144 |
| Number of pages | 14 |
| Journal | International Journal of Neuroscience |
| Volume | 107 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - 2001 |
| Externally published | Yes |
Bibliographical note
Slewa-Younan, S Gordon, E Williams, L Haig, A R Goldberg, E Journal Article England Int J Neurosci. 2001 Mar;107(1-2):131-44. doi: 10.3109/00207450109149762.Keywords
- Acoustic Stimulation Adult Brain/*physiology Brain Mapping *Electroencephalography Female Functional Laterality/physiology Humans Male Reaction Time/physiology Schizophrenia/*physiopathology Sex Factors