TY - JOUR
T1 - Signaling pathways and bone marrow microenvironment in myelodysplastic neoplasms
AU - Ceneri, Eleonora
AU - De Stefano, Alessia
AU - Casalin, Irene
AU - Finelli, Carlo
AU - Curti, Antonio
AU - Paolini, Stefania
AU - Parisi, Sarah
AU - Ardizzoia, Federica
AU - Cristiano, Gianluca
AU - Boultwood, Jaqueline
AU - McCubrey, James A.
AU - Suh, Pann Ghill
AU - Ramazzotti, Giulia
AU - Fiume, Roberta
AU - Ratti, Stefano
AU - Manzoli, Lucia
AU - Cocco, Lucio
AU - Follo, Matilde Y.
PY - 2025/1
Y1 - 2025/1
N2 - Key signaling pathways within the Bone Marrow Microenvironment (BMM), such as Notch, Phosphoinositide-Specific Phospholipase C (PI-PLCs), Transforming Growth Factor β (TGF-β), and Nuclear Factor Kappa B (NF-κB), play a vital role in the progression of Myelodysplastic Neoplasms (MDS). Among the various BMM cell types, Mesenchymal Stromal Cells (MSCs) are particularly central to these pathways. While these signaling routes can independently affect both MSCs and Hematopoietic Stem Cells (HSCs), they most importantly alter the dynamics of their interactions, leading to abnormal changes in survival, differentiation, and quiescence. Notch and PI-PLC signaling facilitate intercellular communication, TGF-β promotes quiescence and suppresses hematopoiesis, and NF-κB-driven inflammatory responses foster an environment detrimental to normal hematopoiesis. This review highlights the role of these pathways within the MDS microenvironment, driving the development and progression of the disease and paving the way for new possible therapeutic strategies.
AB - Key signaling pathways within the Bone Marrow Microenvironment (BMM), such as Notch, Phosphoinositide-Specific Phospholipase C (PI-PLCs), Transforming Growth Factor β (TGF-β), and Nuclear Factor Kappa B (NF-κB), play a vital role in the progression of Myelodysplastic Neoplasms (MDS). Among the various BMM cell types, Mesenchymal Stromal Cells (MSCs) are particularly central to these pathways. While these signaling routes can independently affect both MSCs and Hematopoietic Stem Cells (HSCs), they most importantly alter the dynamics of their interactions, leading to abnormal changes in survival, differentiation, and quiescence. Notch and PI-PLC signaling facilitate intercellular communication, TGF-β promotes quiescence and suppresses hematopoiesis, and NF-κB-driven inflammatory responses foster an environment detrimental to normal hematopoiesis. This review highlights the role of these pathways within the MDS microenvironment, driving the development and progression of the disease and paving the way for new possible therapeutic strategies.
KW - Bone marrow microenvironment
KW - Myelodysplastic neoplasms
KW - NF-κB signaling
KW - Notch signaling
KW - Phosphoinositide signaling
KW - TGF-β signaling
UR - http://www.scopus.com/inward/record.url?scp=85211236221&partnerID=8YFLogxK
U2 - 10.1016/j.jbior.2024.101071
DO - 10.1016/j.jbior.2024.101071
M3 - Article
C2 - 39648082
AN - SCOPUS:85211236221
SN - 2212-4926
VL - 95
JO - Advances in Biological Regulation
JF - Advances in Biological Regulation
M1 - 101071
ER -