TY - JOUR
T1 - Silica particles : a novel drug-delivery system
AU - Barbé, Christophe
AU - Bartlett, John R.
AU - Kong, Linggen
AU - Finnie, Kim S.
AU - Lin, Hui Qiang
AU - Larkin, Michael
AU - Calleja, Sandrine
AU - Bush, Alexandra
AU - Calleja, Gerard
PY - 2004
Y1 - 2004
N2 - In recent decades, significant advances in drug-delivery systems have enabled more effective drug administration. To deliver drugs to specific organs, a range of organic systems (e.g., micelles, liposomes, and polymeric nanoparticles) have been designed. They suffer from limitations, including poor thermal and chemical stability, and rapid elimination by the immune system. In contrast, silica particles offer a biocompatible, stable, and stealthy alternative. Bioactive molecules can be easily encapsulated within silica particles by combining sol-gel polymerization with either spray-drying or emulsion chemistry. Spray-drying faces challenges, including low yield, surface segregation, and size limitations. In contrast, sol-gel emulsions enable the production of nanoparticles with homogeneous drug distribution, and permit ambient temperature processing, necessary for handling biologicals. Independent control of the size and release rate can be readily achieved. Preliminary in-vivo experiments reveal enhanced blood stability of the nanoparticles, which, coupled with sustained release of anti-tumor agents, show good potential for cancer treatment.
AB - In recent decades, significant advances in drug-delivery systems have enabled more effective drug administration. To deliver drugs to specific organs, a range of organic systems (e.g., micelles, liposomes, and polymeric nanoparticles) have been designed. They suffer from limitations, including poor thermal and chemical stability, and rapid elimination by the immune system. In contrast, silica particles offer a biocompatible, stable, and stealthy alternative. Bioactive molecules can be easily encapsulated within silica particles by combining sol-gel polymerization with either spray-drying or emulsion chemistry. Spray-drying faces challenges, including low yield, surface segregation, and size limitations. In contrast, sol-gel emulsions enable the production of nanoparticles with homogeneous drug distribution, and permit ambient temperature processing, necessary for handling biologicals. Independent control of the size and release rate can be readily achieved. Preliminary in-vivo experiments reveal enhanced blood stability of the nanoparticles, which, coupled with sustained release of anti-tumor agents, show good potential for cancer treatment.
KW - colloids
KW - drug delivery devices
KW - drug delivery systems
KW - inorganic compounds
KW - nanoparticles
KW - silica
UR - http://handle.uws.edu.au:8081/1959.7/36508
M3 - Article
SN - 1521-4095
SN - 0935-9648
JO - Advanced Materials
JF - Advanced Materials
ER -