Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization

Puwang Li; Lingxue Kong; Zheng Peng; Yichao Wang

doi:10.4028/www.scientific.net/MSF.654-656.2265

Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization

Puwang Li, Lingxue Kong, Zheng Peng, Yichao Wang

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

Abstract

A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.

Original language	English
Title of host publication	PRICM 7: Proceedings of the 7th Pacific Rim International Conference on Advanced Materials and Processing, 2-6 August, 2010, Cairns, Australia
Publisher	Trans Tech Publications
Pages	2265-2268
Number of pages	4
ISBN (Print)	9780878492558
DOIs	https://doi.org/10.4028/www.scientific.net/MSF.654-656.2265
Publication status	Published - 2010
Event	Pacific Rim International Conference on Advanced Materials and Processing - Duration: 1 Jan 2010 → …

Conference

Conference	Pacific Rim International Conference on Advanced Materials and Processing
Period	1/01/10 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4028/www.scientific.net/MSF.654-656.2265

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Li, P., Kong, L., Peng, Z., & Wang, Y. (2010). Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization. In PRICM 7: Proceedings of the 7th Pacific Rim International Conference on Advanced Materials and Processing, 2-6 August, 2010, Cairns, Australia (pp. 2265-2268). Trans Tech Publications. https://doi.org/10.4028/www.scientific.net/MSF.654-656.2265

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title = "Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization",

abstract = "A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.",

author = "Puwang Li and Lingxue Kong and Zheng Peng and Yichao Wang",

year = "2010",

doi = "10.4028/www.scientific.net/MSF.654-656.2265",

language = "English",

isbn = "9780878492558",

pages = "2265--2268",

booktitle = "PRICM 7: Proceedings of the 7th Pacific Rim International Conference on Advanced Materials and Processing, 2-6 August, 2010, Cairns, Australia",

publisher = "Trans Tech Publications",

note = "Pacific Rim International Conference on Advanced Materials and Processing ; Conference date: 01-01-2010",

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Li, P, Kong, L, Peng, Z & Wang, Y 2010, Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization. in PRICM 7: Proceedings of the 7th Pacific Rim International Conference on Advanced Materials and Processing, 2-6 August, 2010, Cairns, Australia. Trans Tech Publications, pp. 2265-2268, Pacific Rim International Conference on Advanced Materials and Processing, 1/01/10. https://doi.org/10.4028/www.scientific.net/MSF.654-656.2265

Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization. / Li, Puwang; Kong, Lingxue; Peng, Zheng et al.
PRICM 7: Proceedings of the 7th Pacific Rim International Conference on Advanced Materials and Processing, 2-6 August, 2010, Cairns, Australia. Trans Tech Publications, 2010. p. 2265-2268.

Research output: Chapter in Book / Conference Paper › Conference Paper › peer-review

TY - GEN

T1 - Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization

AU - Li, Puwang

AU - Kong, Lingxue

AU - Peng, Zheng

AU - Wang, Yichao

PY - 2010

Y1 - 2010

N2 - A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.

AB - A combined drug loaded system containing two most common anti-cancer drugs 5-fluorouracil (5-FU) and leucovorin (LV) was designed and prepared by ion crosslinking technology. The resulted nanoparticles are spherical in shape, and the particle size becomes larger when drug combination are loaded. Efficient drug encapsulation efficiency (EE) and drug loading (LC) are obtained due to the strong interaction between drugs and polymer. The combined drugs are distributed in the particles in amorpholous state which are demonstrated by the XRD results.

UR - https://hdl.handle.net/1959.7/uws:71299

U2 - 10.4028/www.scientific.net/MSF.654-656.2265

DO - 10.4028/www.scientific.net/MSF.654-656.2265

M3 - Conference Paper

SN - 9780878492558

SP - 2265

EP - 2268

BT - PRICM 7: Proceedings of the 7th Pacific Rim International Conference on Advanced Materials and Processing, 2-6 August, 2010, Cairns, Australia

PB - Trans Tech Publications

T2 - Pacific Rim International Conference on Advanced Materials and Processing

Y2 - 1 January 2010

ER -

Li P, Kong L, Peng Z, Wang Y. Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization. In PRICM 7: Proceedings of the 7th Pacific Rim International Conference on Advanced Materials and Processing, 2-6 August, 2010, Cairns, Australia. Trans Tech Publications. 2010. p. 2265-2268 doi: 10.4028/www.scientific.net/MSF.654-656.2265

Simultaneous incorporation of 5-fluorouracil and leucovorin into chitosan nanoparticle as drug carrier and its characterization

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