Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: A point-counterpoint discussion

Eric P. Brass; William R. Hiatt; Simon Green

doi:10.1191/1358863x04vm572ra

Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: A point-counterpoint discussion

Eric P. Brass
, William R. Hiatt
, Simon Green

University of California at Los Angeles
University of Colorado Anschutz Medical Campus
School of Biological, Biomedical and Molecular Sciences
University of New England

Research output: Contribution to journal › Article › peer-review

62 Citations (Scopus)

Abstract

Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.

Original language	English
Pages (from-to)	293-301
Number of pages	9
Journal	Vascular Medicine
Volume	9
Issue number	4
DOIs	https://doi.org/10.1191/1358863x04vm572ra
Publication status	Published - 2004
Externally published	Yes

Keywords

Blood flow
Intermittent claudication
Muscle metabolism
Peripheral vascular disease

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10.1191/1358863x04vm572ra

Cite this

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title = "Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: A point-counterpoint discussion",

abstract = "Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.",

keywords = "Blood flow, Intermittent claudication, Muscle metabolism, Peripheral vascular disease",

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AU - Brass, Eric P.

AU - Hiatt, William R.

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N2 - Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.

AB - Patients with claudication have a marked impairment in exercise performance. Several factors contribute to this limitation, including reductions in large vessel blood flow and oxygen delivery as well as metabolic abnormalities in skeletal muscle. The relative contribution of these factors and their role in the pathophysiology of the exercise limitation is discussed using a point-counterpoint approach. Future directions for research conclude the discussion.

KW - Blood flow

KW - Intermittent claudication

KW - Muscle metabolism

KW - Peripheral vascular disease

UR - https://www.scopus.com/pages/publications/13444267773

U2 - 10.1191/1358863x04vm572ra

DO - 10.1191/1358863x04vm572ra

M3 - Article

C2 - 15678622

AN - SCOPUS:13444267773

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SP - 293

EP - 301

JO - Vascular Medicine

JF - Vascular Medicine

IS - 4

ER -

Skeletal muscle metabolic changes in peripheral arterial disease contribute to exercise intolerance: A point-counterpoint discussion

Abstract

Keywords

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