Sleep disordered breathing controlled by CPAP and sFlt-1 in a pregnant patient with chronic hypertension : case report and literature review

Amy Daly, Annette Roberson, Gabriele Bobek, Sally Middleton, Colin Sullivan, Annemarie Hennessy

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Background:There is recent interest exploring the possible impact of sleep disordered breathing on the mechanisms of preeclampsia. A biomarker of preeclampsia, soluble fms-like tyrosine kinase-1, has come to prominence in recent years. The aim of this study was to investigate the relationship between continuous positive airway pressure treatment, sleep disordered breathing and soluble fms-like tyrosine kinase-1 concentrations during pregnancy. Methods: A 38-year-old G1P0 presented at 20 + 5 weeks. She had a history of chronic hypertension. Sleep studies revealed she had sleep disordered breathing with an AHI of 7.3/h. She was commenced on continuous positive airway pressure. Soluble fms-like tyrosine kinase-1 concentrations and blood pressure recordings were taken at various points during her pregnancy. Results: She did not develop preeclampsia or require an escalation in her antihypertensives. Soluble fms-like tyrosine kinase-1 concentrations rose 16% from a low baseline. She remained compliant with her continuous positive airway pressure. She progressed to birth a well, live, term baby. Conclusion: Continuous positive airway pressure treatment controlled sleep disordered breathing in a high risk pregnant woman with chronic hypertension with no increase in soluble fms-like tyrosine kinase-1 concentrations.
Original languageEnglish
Pages (from-to)32-34
Number of pages3
JournalObstetric Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - 2018

Keywords

  • hypertension
  • hypnotics

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