Smell-related quality of life changes after total laryngectomy : a multi-centre study

Eugene Wong; Murray Smith; Malcolm A. Buchanan; Akshay Kudpaje; Andrew Williamson; Prasanna Suresh Hedge; Daniel Hazan; Jordan Idaire; Mark C. Smith; Niranjan Sritharan; Carsten Palme; Faruque Riffat

doi:10.1007/s00405-023-07976-0

Smell-related quality of life changes after total laryngectomy : a multi-centre study

Eugene Wong, Murray Smith, Malcolm A. Buchanan, Akshay Kudpaje, Andrew Williamson, Prasanna Suresh Hedge, Daniel Hazan, Jordan Idaire, Mark C. Smith, Niranjan Sritharan, Carsten Palme, Faruque Riffat

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Purpose: A total laryngectomy creates an alternate airway for gas exchange that bypasses the upper aerodigestive tract. The subsequent reduction in nasal airflow, and therefore, reduction in deposition of particles to the olfactory neuroepithelium leads to hyposmia or anosmia. The aim of this study was to assess the quality of life impairment conferred by anosmia following laryngectomy and identify any specific patient-related risk factors that are associated with poorer outcomes. Methods: Consecutive patients with a total laryngectomy presenting for review at three tertiary head and neck services (in Australia, the United Kingdom and India) over a 12-month period were recruited. Patient demographic and clinical data were collected, and each subject completed the validated assessment of self-reported olfactory functioning and olfaction-related quality of life questionnaire (ASOF). Dichotomous comparisons were performed using the student's unpaired t-test for continuous variables (SRP), a chi-squared test for categorical variables, and a Kendall's tau-b for ordinal variables (SOC) to assess for a correlation with poorer questionnaire scores. Results: A total of 66 laryngectomees (13.4% female; age 65.7 ± 8.6 years) were included in the study. The mean SRP score of the cohort was found to be 15.6 ± 7.4, while the mean ORQ score was noted to be 16.4 ± 8.1. No other specific risk factors associated with poorer quality of life were identified. Conclusion: A significant quality of life detriment from hyposmia is conferred following laryngectomy. Further research to assess treatment options and the patient population that would best benefit from these interventions is required.

Original language	English
Pages (from-to)	3861-3866
Number of pages	6
Journal	European Archives of Oto-Rhino-Laryngology
Volume	280
Issue number	8
DOIs	https://doi.org/10.1007/s00405-023-07976-0
Publication status	Published - Aug 2023

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© 2023, The Author(s).

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title = "Smell-related quality of life changes after total laryngectomy : a multi-centre study",

abstract = "Purpose: A total laryngectomy creates an alternate airway for gas exchange that bypasses the upper aerodigestive tract. The subsequent reduction in nasal airflow, and therefore, reduction in deposition of particles to the olfactory neuroepithelium leads to hyposmia or anosmia. The aim of this study was to assess the quality of life impairment conferred by anosmia following laryngectomy and identify any specific patient-related risk factors that are associated with poorer outcomes. Methods: Consecutive patients with a total laryngectomy presenting for review at three tertiary head and neck services (in Australia, the United Kingdom and India) over a 12-month period were recruited. Patient demographic and clinical data were collected, and each subject completed the validated assessment of self-reported olfactory functioning and olfaction-related quality of life questionnaire (ASOF). Dichotomous comparisons were performed using the student's unpaired t-test for continuous variables (SRP), a chi-squared test for categorical variables, and a Kendall's tau-b for ordinal variables (SOC) to assess for a correlation with poorer questionnaire scores. Results: A total of 66 laryngectomees (13.4% female; age 65.7 ± 8.6 years) were included in the study. The mean SRP score of the cohort was found to be 15.6 ± 7.4, while the mean ORQ score was noted to be 16.4 ± 8.1. No other specific risk factors associated with poorer quality of life were identified. Conclusion: A significant quality of life detriment from hyposmia is conferred following laryngectomy. Further research to assess treatment options and the patient population that would best benefit from these interventions is required.",

author = "Eugene Wong and Murray Smith and Buchanan, {Malcolm A.} and Akshay Kudpaje and Andrew Williamson and Hedge, {Prasanna Suresh} and Daniel Hazan and Jordan Idaire and Smith, {Mark C.} and Niranjan Sritharan and Carsten Palme and Faruque Riffat",

note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",

year = "2023",

month = aug,

doi = "10.1007/s00405-023-07976-0",

language = "English",

volume = "280",

pages = "3861--3866",

journal = "European Archives of Oto-Rhino-Laryngology",

issn = "0937-4477",

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}

TY - JOUR

T1 - Smell-related quality of life changes after total laryngectomy : a multi-centre study

AU - Wong, Eugene

AU - Smith, Murray

AU - Buchanan, Malcolm A.

AU - Kudpaje, Akshay

AU - Williamson, Andrew

AU - Hedge, Prasanna Suresh

AU - Hazan, Daniel

AU - Idaire, Jordan

AU - Smith, Mark C.

AU - Sritharan, Niranjan

AU - Palme, Carsten

AU - Riffat, Faruque

PY - 2023/8

Y1 - 2023/8

N2 - Purpose: A total laryngectomy creates an alternate airway for gas exchange that bypasses the upper aerodigestive tract. The subsequent reduction in nasal airflow, and therefore, reduction in deposition of particles to the olfactory neuroepithelium leads to hyposmia or anosmia. The aim of this study was to assess the quality of life impairment conferred by anosmia following laryngectomy and identify any specific patient-related risk factors that are associated with poorer outcomes. Methods: Consecutive patients with a total laryngectomy presenting for review at three tertiary head and neck services (in Australia, the United Kingdom and India) over a 12-month period were recruited. Patient demographic and clinical data were collected, and each subject completed the validated assessment of self-reported olfactory functioning and olfaction-related quality of life questionnaire (ASOF). Dichotomous comparisons were performed using the student's unpaired t-test for continuous variables (SRP), a chi-squared test for categorical variables, and a Kendall's tau-b for ordinal variables (SOC) to assess for a correlation with poorer questionnaire scores. Results: A total of 66 laryngectomees (13.4% female; age 65.7 ± 8.6 years) were included in the study. The mean SRP score of the cohort was found to be 15.6 ± 7.4, while the mean ORQ score was noted to be 16.4 ± 8.1. No other specific risk factors associated with poorer quality of life were identified. Conclusion: A significant quality of life detriment from hyposmia is conferred following laryngectomy. Further research to assess treatment options and the patient population that would best benefit from these interventions is required.

AB - Purpose: A total laryngectomy creates an alternate airway for gas exchange that bypasses the upper aerodigestive tract. The subsequent reduction in nasal airflow, and therefore, reduction in deposition of particles to the olfactory neuroepithelium leads to hyposmia or anosmia. The aim of this study was to assess the quality of life impairment conferred by anosmia following laryngectomy and identify any specific patient-related risk factors that are associated with poorer outcomes. Methods: Consecutive patients with a total laryngectomy presenting for review at three tertiary head and neck services (in Australia, the United Kingdom and India) over a 12-month period were recruited. Patient demographic and clinical data were collected, and each subject completed the validated assessment of self-reported olfactory functioning and olfaction-related quality of life questionnaire (ASOF). Dichotomous comparisons were performed using the student's unpaired t-test for continuous variables (SRP), a chi-squared test for categorical variables, and a Kendall's tau-b for ordinal variables (SOC) to assess for a correlation with poorer questionnaire scores. Results: A total of 66 laryngectomees (13.4% female; age 65.7 ± 8.6 years) were included in the study. The mean SRP score of the cohort was found to be 15.6 ± 7.4, while the mean ORQ score was noted to be 16.4 ± 8.1. No other specific risk factors associated with poorer quality of life were identified. Conclusion: A significant quality of life detriment from hyposmia is conferred following laryngectomy. Further research to assess treatment options and the patient population that would best benefit from these interventions is required.

UR - https://hdl.handle.net/1959.7/uws:71954

U2 - 10.1007/s00405-023-07976-0

DO - 10.1007/s00405-023-07976-0

M3 - Article

SN - 0937-4477

VL - 280

SP - 3861

EP - 3866

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

IS - 8

ER -

Smell-related quality of life changes after total laryngectomy : a multi-centre study

Abstract

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