Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds

Alexander E. Dunn; Douglas J. Dunn; Alexander Macmillan; Renee Whan; Tim Stait-Gardner; William S. Price; May Lim; Cyrille Boyer

doi:10.1039/c4py00150h

Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds

Alexander E. Dunn, Douglas J. Dunn, Alexander Macmillan, Renee Whan, Tim Stait-Gardner, William S. Price, May Lim, Cyrille Boyer

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

P(DEGMA-co-OEGMA-b-[TMSPMA-co-VBA])@silica@magnetite polymer-nanoparticle composites have been developed as a platform for controllable drug release. The nanocomposite facilitates controllable release of therapeutic molecules through breakage of pH and heat labile Schiff base bonds that bind the molecules to the polymer. This enables dual-stimuli responsive drug release in response to the acidic microenvironment of cancerous cells and heat generated by the magnetite nanoparticles when subjected to an alternating magnetic field, thereby permitting spatial and temporal control over 'burst' release of the drugs. The nanocomposite has also been shown to be effective at improving magnetic resonance imaging contrast through enhancement of spin-spin relaxivity.

Original language	English
Pages (from-to)	3311-3315
Number of pages	5
Journal	Polymer Chemistry
Volume	5
Issue number	10
DOIs	https://doi.org/10.1039/c4py00150h
Publication status	Published - 2014

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title = "Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds",

abstract = "P(DEGMA-co-OEGMA-b-[TMSPMA-co-VBA])@silica@magnetite polymer-nanoparticle composites have been developed as a platform for controllable drug release. The nanocomposite facilitates controllable release of therapeutic molecules through breakage of pH and heat labile Schiff base bonds that bind the molecules to the polymer. This enables dual-stimuli responsive drug release in response to the acidic microenvironment of cancerous cells and heat generated by the magnetite nanoparticles when subjected to an alternating magnetic field, thereby permitting spatial and temporal control over 'burst' release of the drugs. The nanocomposite has also been shown to be effective at improving magnetic resonance imaging contrast through enhancement of spin-spin relaxivity.",

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T1 - Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds

AU - Dunn, Alexander E.

AU - Dunn, Douglas J.

AU - Macmillan, Alexander

AU - Whan, Renee

AU - Stait-Gardner, Tim

AU - Price, William S.

AU - Lim, May

AU - Boyer, Cyrille

PY - 2014

Y1 - 2014

N2 - P(DEGMA-co-OEGMA-b-[TMSPMA-co-VBA])@silica@magnetite polymer-nanoparticle composites have been developed as a platform for controllable drug release. The nanocomposite facilitates controllable release of therapeutic molecules through breakage of pH and heat labile Schiff base bonds that bind the molecules to the polymer. This enables dual-stimuli responsive drug release in response to the acidic microenvironment of cancerous cells and heat generated by the magnetite nanoparticles when subjected to an alternating magnetic field, thereby permitting spatial and temporal control over 'burst' release of the drugs. The nanocomposite has also been shown to be effective at improving magnetic resonance imaging contrast through enhancement of spin-spin relaxivity.

AB - P(DEGMA-co-OEGMA-b-[TMSPMA-co-VBA])@silica@magnetite polymer-nanoparticle composites have been developed as a platform for controllable drug release. The nanocomposite facilitates controllable release of therapeutic molecules through breakage of pH and heat labile Schiff base bonds that bind the molecules to the polymer. This enables dual-stimuli responsive drug release in response to the acidic microenvironment of cancerous cells and heat generated by the magnetite nanoparticles when subjected to an alternating magnetic field, thereby permitting spatial and temporal control over 'burst' release of the drugs. The nanocomposite has also been shown to be effective at improving magnetic resonance imaging contrast through enhancement of spin-spin relaxivity.

UR - http://handle.uws.edu.au:8081/1959.7/543171

U2 - 10.1039/c4py00150h

DO - 10.1039/c4py00150h

M3 - Article

SN - 1759-9954

VL - 5

SP - 3311

EP - 3315

JO - Polymer Chemistry

JF - Polymer Chemistry

IS - 10

ER -

Spatial and temporal control of drug release through pH and alternating magnetic field induced breakage of Schiff base bonds

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