Abstract
The mechanisms underpinning the latter stages of spermiogenesis are poorly understood and male germ cells have been presumed to extensively employ post-transcriptional regulatory machinery, in order to produce the highly differentiated spermatozoa, in the absence of newly synthesized gene transcripts. Excitingly, in a recently published paper in the Journal of Clinical Investigation, two groups at McGill University, using null mouse models, have identified a crucial role of the poly(A)-binding protein-interacting protein 2 (Paip2a), in translational activation and protein homeostasis in the transcriptionally quiescent and terminally differentiating elongating spermatids.
| Original language | English |
|---|---|
| Pages (from-to) | 122-124 |
| Number of pages | 3 |
| Journal | Asian Journal of Andrology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 |
Open Access - Access Right Statement
Article published under the Creative Commons Attribution‐NonCommercial‐Share Alike 3.0 license (https://creativecommons.org/licenses/by-nc-sa/3.0/au/). This allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted. Ownership of copyright remains with the Authors, and provided that, when reproducing the Contribution or extracts from it, they acknowledge first and reference publication in the Journal.Keywords
- RNA, protein interactions
- gene expression
- spermiogenesis