Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Angela M. Hong; Andrew E. Grulich; Deanna Jones; Cheok Soon Lee; Suzanne M. Garland; Timothy A. Dobbins; Jonathan R. Clark; Gerald B. Harnett; Christopher G. Milross; Christopher J. O'Brien; Barbara R. Rose

Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Angela M. Hong, Andrew E. Grulich, Deanna Jones, Cheok Soon Lee, Suzanne M. Garland, Timothy A. Dobbins, Jonathan R. Clark, Gerald B. Harnett, Christopher G. Milross, Christopher J. O'Brien, Barbara R. Rose

Research output: Contribution to journal › Article

130 Citations (Scopus)

Abstract

This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987Ã¢â‚¬â€œ1990) to 47% (2001Ã¢â‚¬â€œ2005). HPV data used in conjunction with Australian cancer incidence data 2001Ã¢â‚¬â€œ2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.

Original language	English
Pages (from-to)	3269-3272
Number of pages	4
Journal	Vaccine
Volume	28
Issue number	19
Publication status	Published - 2010

Keywords

human papillomavirus
oropharyngeal cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets",

abstract = "This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987{\~A}¢{\^a}‚¬{\^a}€{\oe}1990) to 47% (2001{\~A}¢{\^a}‚¬{\^a}€{\oe}2005). HPV data used in conjunction with Australian cancer incidence data 2001{\~A}¢{\^a}‚¬{\^a}€{\oe}2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.",

keywords = "human papillomavirus, oropharyngeal cancer",

author = "Hong, {Angela M.} and Grulich, {Andrew E.} and Deanna Jones and Lee, {Cheok Soon} and Garland, {Suzanne M.} and Dobbins, {Timothy A.} and Clark, {Jonathan R.} and Harnett, {Gerald B.} and Milross, {Christopher G.} and O'Brien, {Christopher J.} and Rose, {Barbara R.}",

year = "2010",

language = "English",

volume = "28",

pages = "3269--3272",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier",

number = "19",

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TY - JOUR

T1 - Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

AU - Hong, Angela M.

AU - Grulich, Andrew E.

AU - Jones, Deanna

AU - Lee, Cheok Soon

AU - Garland, Suzanne M.

AU - Dobbins, Timothy A.

AU - Clark, Jonathan R.

AU - Harnett, Gerald B.

AU - Milross, Christopher G.

AU - O'Brien, Christopher J.

AU - Rose, Barbara R.

PY - 2010

Y1 - 2010

N2 - This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987Ã¢â‚¬â€œ1990) to 47% (2001Ã¢â‚¬â€œ2005). HPV data used in conjunction with Australian cancer incidence data 2001Ã¢â‚¬â€œ2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.

AB - This study provides Australian data on the incidence of human papillomavirus (HPV)-related oropharyngeal cancer to aid the debate on extending the HPV vaccination programme to males. The HPV status for 302 oropharyngeal cancers diagnosed between 1987 and 2006 was determined by HPV E6-targeted multiplex real-time PCR/p16 immunohistochemistry. The overall HPV-positivity rate was 36% (94% types 16 and 18). HPV-related cancer increased from 19% (1987Ã¢â‚¬â€œ1990) to 47% (2001Ã¢â‚¬â€œ2005). HPV data used in conjunction with Australian cancer incidence data 2001Ã¢â‚¬â€œ2005 showed that 1.56 cases of oropharyngeal cancer per 100,000 males per year were associated with HPV types targeted by the vaccine. Vaccinating males may substantially reduce the burden of oropharyngeal cancer in Australia.

KW - human papillomavirus

KW - oropharyngeal cancer

UR - http://handle.uws.edu.au:8081/1959.7/503203

M3 - Article

SN - 0264-410X

VL - 28

SP - 3269

EP - 3272

JO - Vaccine

JF - Vaccine

IS - 19

ER -

Squamous cell carcinoma of the oropharynx in Australian males induced by human papillomavirus vaccine targets

Abstract

Keywords

UN SDGs

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