St. John's Wort (Hypericum perforatum) in the treatment of depression

Jerome Sarris

St. John's Wort (Hypericum perforatum) in the treatment of depression

Jerome Sarris

Western Sydney University

Research output: Chapter in Book / Conference Paper › Chapter

Abstract

St. John's wort (Hypericum perforatum; SJW), traditionally used for a variety of nervous system conditions, is a popular modern-day herbal treatment for depression. Many clinical trials consistently demonstrate SJW's effectiveness in major depressive disorder (MDD); several have shown it to be equivalent to pharmaceutical antidepressants (Sarris 2013). However, because most of these studies used highly characterized, standardized SJW preparations, the findings cannot be extrapolated to all over-the-counter SJW supplements. In this chapter, I discuss the mechanisms of action of SJW, emerging pharmacogenetic data, current evidence of the efficacy of SJW in treating depression, safety and clinical considerations, and a case study.

Original language	English
Title of host publication	Complementary and Integrative Treatments in Psychiatric Practice
Editors	Patricia L. Gerbarg, Philip R. Muskin, Richard P. Brown
Place of Publication	U.S.
Publisher	American Psychiatric Association
Pages	143-148
Number of pages	6
ISBN (Electronic)	9781615371358
ISBN (Print)	9781615370313
Publication status	Published - 2017

Keywords

St John's wort
depression, mental

Cite this

@inbook{2f172b9f58d143669c8cbb9c0ee909c4,

title = "St. John's Wort (Hypericum perforatum) in the treatment of depression",

abstract = "St. John's wort (Hypericum perforatum; SJW), traditionally used for a variety of nervous system conditions, is a popular modern-day herbal treatment for depression. Many clinical trials consistently demonstrate SJW's effectiveness in major depressive disorder (MDD); several have shown it to be equivalent to pharmaceutical antidepressants (Sarris 2013). However, because most of these studies used highly characterized, standardized SJW preparations, the findings cannot be extrapolated to all over-the-counter SJW supplements. In this chapter, I discuss the mechanisms of action of SJW, emerging pharmacogenetic data, current evidence of the efficacy of SJW in treating depression, safety and clinical considerations, and a case study.",

keywords = "St John's wort, depression, mental",

author = "Jerome Sarris",

year = "2017",

language = "English",

isbn = "9781615370313",

pages = "143--148",

editor = "Gerbarg, {Patricia L.} and Muskin, {Philip R.} and Brown, {Richard P.}",

booktitle = "Complementary and Integrative Treatments in Psychiatric Practice",

publisher = "American Psychiatric Association",

}

TY - CHAP

T1 - St. John's Wort (Hypericum perforatum) in the treatment of depression

AU - Sarris, Jerome

PY - 2017

Y1 - 2017

N2 - St. John's wort (Hypericum perforatum; SJW), traditionally used for a variety of nervous system conditions, is a popular modern-day herbal treatment for depression. Many clinical trials consistently demonstrate SJW's effectiveness in major depressive disorder (MDD); several have shown it to be equivalent to pharmaceutical antidepressants (Sarris 2013). However, because most of these studies used highly characterized, standardized SJW preparations, the findings cannot be extrapolated to all over-the-counter SJW supplements. In this chapter, I discuss the mechanisms of action of SJW, emerging pharmacogenetic data, current evidence of the efficacy of SJW in treating depression, safety and clinical considerations, and a case study.

AB - St. John's wort (Hypericum perforatum; SJW), traditionally used for a variety of nervous system conditions, is a popular modern-day herbal treatment for depression. Many clinical trials consistently demonstrate SJW's effectiveness in major depressive disorder (MDD); several have shown it to be equivalent to pharmaceutical antidepressants (Sarris 2013). However, because most of these studies used highly characterized, standardized SJW preparations, the findings cannot be extrapolated to all over-the-counter SJW supplements. In this chapter, I discuss the mechanisms of action of SJW, emerging pharmacogenetic data, current evidence of the efficacy of SJW in treating depression, safety and clinical considerations, and a case study.

KW - St John's wort

KW - depression, mental

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:43363

M3 - Chapter

SN - 9781615370313

SP - 143

EP - 148

BT - Complementary and Integrative Treatments in Psychiatric Practice

A2 - Gerbarg, Patricia L.

A2 - Muskin, Philip R.

A2 - Brown, Richard P.

PB - American Psychiatric Association

CY - U.S.

ER -

St. John's Wort (Hypericum perforatum) in the treatment of depression

Abstract

Keywords

Other files and links

Fingerprint

Cite this