Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

Ashour Sliow; Zhi Ma; Gaetano Gargiulo; David Mahns; Damia Mawad; Paul Breen; Marcus Stoodley; Jessica Houang; Rhiannon Kuchel; Giuseppe C. Tettamanzi; Richard D. Tilley; Samuel J. Frost; John Morley; Leonardo Longo; Antonio Lauto

doi:10.1002/advs.201801212

Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

Ashour Sliow, Zhi Ma, Gaetano Gargiulo, David Mahns, Damia Mawad, Paul Breen, Marcus Stoodley, Jessica Houang, Rhiannon Kuchel, Giuseppe C. Tettamanzi, Richard D. Tilley, Samuel J. Frost, John Morley, Leonardo Longo, Antonio Lauto

Western Sydney University

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft‐antenna). The graft‐antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft‐antenna and stimulated by the TMS for 1 h per week. The graft‐antenna is an innovative and minimally‐invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

Original language	English
Article number	1801212
Number of pages	13
Journal	Advanced Science
Volume	6
Issue number	11
DOIs	https://doi.org/10.1002/advs.201801212
Publication status	Published - 2019

Open Access - Access Right Statement

© 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits use, distribution and re- production in any medium, provided the original work is properly cited.

Keywords

chitosan
lasers
neural stimulation
photochemistry

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10.1002/advs.201801212

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title = "Stimulation and repair of peripheral nerves using bioadhesive graft-antenna",

abstract = "An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft‐antenna). The graft‐antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft‐antenna and stimulated by the TMS for 1 h per week. The graft‐antenna is an innovative and minimally‐invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.",

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AU - Sliow, Ashour

AU - Ma, Zhi

AU - Gargiulo, Gaetano

AU - Mahns, David

AU - Mawad, Damia

AU - Breen, Paul

AU - Stoodley, Marcus

AU - Houang, Jessica

AU - Kuchel, Rhiannon

AU - Tettamanzi, Giuseppe C.

AU - Tilley, Richard D.

AU - Frost, Samuel J.

AU - Morley, John

AU - Longo, Leonardo

AU - Lauto, Antonio

PY - 2019

Y1 - 2019

N2 - An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft‐antenna). The graft‐antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft‐antenna and stimulated by the TMS for 1 h per week. The graft‐antenna is an innovative and minimally‐invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

AB - An original wireless stimulator for peripheral nerves based on a metal loop (diameter ≈1 mm) that is powered by a transcranial magnetic stimulator (TMS) and does not require circuitry components is reported. The loop can be integrated in a chitosan scaffold that functions as a graft when applied onto transected nerves (graft‐antenna). The graft‐antenna is bonded to rat sciatic nerves by a laser without sutures; it does not migrate after implantation and is able to trigger steady compound muscle action potentials for 12 weeks (CMAP ≈1.3 mV). Eight weeks postoperatively, axon regeneration is facilitated in transected nerves that are repaired with the graft‐antenna and stimulated by the TMS for 1 h per week. The graft‐antenna is an innovative and minimally‐invasive device that functions concurrently as a wireless stimulator and adhesive scaffold for nerve repair.

KW - chitosan

KW - lasers

KW - neural stimulation

KW - photochemistry

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:50811

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DO - 10.1002/advs.201801212

M3 - Article

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VL - 6

JO - Advanced Science

JF - Advanced Science

IS - 11

M1 - 1801212

ER -

Stimulation and repair of peripheral nerves using bioadhesive graft-antenna

Abstract

Open Access - Access Right Statement

Keywords

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