Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans

L. S. Crawford; N. Meylakh; P. M. Macey; Vaughan G. Macefield; K. A. Keay; L. A. Henderson

doi:10.1038/s42003-023-04951-7

Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans

L. S. Crawford, N. Meylakh, P. M. Macey, Vaughan G. Macefield, K. A. Keay, L. A. Henderson

Western Sydney University

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The neural circuits that regulate placebo analgesia responsivity are unknown, although engagement of brainstem pain modulatory regions is likely critical. Here we show in 47 participants that differences are present in neural circuit connectivity's in placebo responders versus non-responders. We distinguish stimulus-independent and stimulus-dependent neural networks that display altered connections between the hypothalamus, anterior cingulate cortex and midbrain periaqueductal gray matter. This dual regulatory system underpins an individual's ability to mount placebo analgesia.

Original language	English
Article number	569
Number of pages	11
Journal	Communications Biology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1038/s42003-023-04951-7
Publication status	Published - Dec 2023

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© 2023, Crown.

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Stimulus-independent and stimulus-dependent neural networks underpin placebo analgesia responsiveness in humans

Abstract

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