Strong association between pseudogenization mechanisms and gene sequence length

Amit N. Khachane; Paul M. Harrison

doi:10.1186/1745-6150-4-38

Strong association between pseudogenization mechanisms and gene sequence length

Amit N. Khachane, Paul M. Harrison

Research output: Contribution to journal › Article › peer-review

Abstract

Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the opposite is true for processed pseudogenes. Protein-coding genes longer than 3000 bp are 6 times more likely to produce nonprocessed pseudogenes than processed ones.

Original language	English
Article number	1745
Number of pages	5
Journal	Biology Direct
Volume	4
DOIs	https://doi.org/10.1186/1745-6150-4-38
Publication status	Published - 2009

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title = "Strong association between pseudogenization mechanisms and gene sequence length",

abstract = "Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the opposite is true for processed pseudogenes. Protein-coding genes longer than 3000 bp are 6 times more likely to produce nonprocessed pseudogenes than processed ones.",

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AU - Harrison, Paul M.

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AB - Pseudogenes arise from the decay of gene copies following either RNA-mediated duplication (processed pseudogenes) or DNA-mediated duplication (nonprocessed pseudogenes). Here, we show that long protein-coding genes tend to produce more nonprocessed pseudogenes than short genes, whereas the opposite is true for processed pseudogenes. Protein-coding genes longer than 3000 bp are 6 times more likely to produce nonprocessed pseudogenes than processed ones.

UR - http://handle.uws.edu.au:8081/1959.7/531244

UR - http://www.biologydirect.com/content/4/1/38

U2 - 10.1186/1745-6150-4-38

DO - 10.1186/1745-6150-4-38

M3 - Article

SN - 1745-6150

VL - 4

JO - Biology Direct

JF - Biology Direct

M1 - 1745

ER -

Strong association between pseudogenization mechanisms and gene sequence length

Abstract

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