Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility

Z. Yu, J. Tan, A. McMahon, S. Iismaa, X. Xiao, S. Kesteven, M Reichelt, M. Mohl, Y. Dai, A. Sketchley, L. Yang, H. Gong, D. Fatkin, D. Allen, S. Head, R. Graham, M. Feneley

Research output: Contribution to journalArticlepeer-review

Abstract

Despite evidence implicating the _1A-adrenergic receptor (AR) in the development of cardiac hypertrophy, we have previously reported that transgenic (TG) mice with cardiac-restricted _1A-AR overexpression (170-fold) exhibit enhanced ventricular contractility but not hypertrophy in vivo.
Original languageEnglish
Pages (from-to)S59-S59
Number of pages1
JournalHeart , Lung and Circulation
Volume22
Issue numberSupplement 1
DOIs
Publication statusPublished - 2013

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