Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility

Z. Yu; J. Tan; A. McMahon; S. Iismaa; X. Xiao; S. Kesteven; M Reichelt; M. Mohl; Y. Dai; A. Sketchley; L. Yang; H. Gong; D. Fatkin; D. Allen; S. Head; R. Graham; M. Feneley

doi:10.1016/j.hlc.2013.05.143

Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility

Z. Yu
, J. Tan
, A. McMahon
, S. Iismaa
, X. Xiao
, S. Kesteven
, M Reichelt
, M. Mohl
, Y. Dai
, A. Sketchley
, L. Yang
, H. Gong
, D. Fatkin
, D. Allen
, S. Head
, R. Graham
, M. Feneley

Research output: Contribution to journal › Article › peer-review

Abstract

Despite evidence implicating the _1A-adrenergic receptor (AR) in the development of cardiac hypertrophy, we have previously reported that transgenic (TG) mice with cardiac-restricted _1A-AR overexpression (170-fold) exhibit enhanced ventricular contractility but not hypertrophy in vivo.

Original language	English
Pages (from-to)	S59-S59
Number of pages	1
Journal	Heart , Lung and Circulation
Volume	22
Issue number	Supplement 1
DOIs	https://doi.org/10.1016/j.hlc.2013.05.143
Publication status	Published - 2013

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10.1016/j.hlc.2013.05.143

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Yu, Z., Tan, J., McMahon, A., Iismaa, S., Xiao, X., Kesteven, S., Reichelt, M., Mohl, M., Dai, Y., Sketchley, A., Yang, L., Gong, H., Fatkin, D., Allen, D., Head, S., Graham, R., & Feneley, M. (2013). Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility. Heart , Lung and Circulation, 22(Supplement 1), S59-S59. https://doi.org/10.1016/j.hlc.2013.05.143

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title = "Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility",

abstract = "Despite evidence implicating the \_1A-adrenergic receptor (AR) in the development of cardiac hypertrophy, we have previously reported that transgenic (TG) mice with cardiac-restricted \_1A-AR overexpression (170-fold) exhibit enhanced ventricular contractility but not hypertrophy in vivo.",

author = "Z. Yu and J. Tan and A. McMahon and S. Iismaa and X. Xiao and S. Kesteven and M Reichelt and M. Mohl and Y. Dai and A. Sketchley and L. Yang and H. Gong and D. Fatkin and D. Allen and S. Head and R. Graham and M. Feneley",

year = "2013",

doi = "10.1016/j.hlc.2013.05.143",

language = "English",

volume = "22",

pages = "S59--S59",

journal = "Heart , Lung and Circulation",

issn = "1443-9506",

publisher = "Elsevier",

number = "Supplement 1",

}

Yu, Z, Tan, J, McMahon, A, Iismaa, S, Xiao, X, Kesteven, S, Reichelt, M, Mohl, M, Dai, Y, Sketchley, A, Yang, L, Gong, H, Fatkin, D, Allen, D, Head, S, Graham, R & Feneley, M 2013, 'Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility', Heart , Lung and Circulation, vol. 22, no. Supplement 1, pp. S59-S59. https://doi.org/10.1016/j.hlc.2013.05.143

TY - JOUR

T1 - Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility

AU - Yu, Z.

AU - Tan, J.

AU - McMahon, A.

AU - Iismaa, S.

AU - Xiao, X.

AU - Kesteven, S.

AU - Reichelt, M

AU - Mohl, M.

AU - Dai, Y.

AU - Sketchley, A.

AU - Yang, L.

AU - Gong, H.

AU - Fatkin, D.

AU - Allen, D.

AU - Head, S.

AU - Graham, R.

AU - Feneley, M.

PY - 2013

Y1 - 2013

N2 - Despite evidence implicating the _1A-adrenergic receptor (AR) in the development of cardiac hypertrophy, we have previously reported that transgenic (TG) mice with cardiac-restricted _1A-AR overexpression (170-fold) exhibit enhanced ventricular contractility but not hypertrophy in vivo.

AB - Despite evidence implicating the _1A-adrenergic receptor (AR) in the development of cardiac hypertrophy, we have previously reported that transgenic (TG) mice with cardiac-restricted _1A-AR overexpression (170-fold) exhibit enhanced ventricular contractility but not hypertrophy in vivo.

UR - http://hdl.handle.net/1959.7/uws:42205

U2 - 10.1016/j.hlc.2013.05.143

DO - 10.1016/j.hlc.2013.05.143

M3 - Article

SN - 1443-9506

VL - 22

SP - S59-S59

JO - Heart , Lung and Circulation

JF - Heart , Lung and Circulation

IS - Supplement 1

ER -

Studies of a mouse model of cardic c a1A-adrenergic receptor over expression provide evidence for a critical role of RhoA/ROCK signalling in cardiac contractility

Abstract

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