Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa

E. Parker; V. Flood; M. Halaki; Christine Wearne; G. Anderson; L. Gomes; S. Clarke; F. Wilson; J. Russell; E. Frig; Michael Kohn

doi:10.1136/bmjopen-2020-038242

Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa

E. Parker, V. Flood, M. Halaki, Christine Wearne, G. Anderson, L. Gomes, S. Clarke, F. Wilson, J. Russell, E. Frig, Michael Kohn

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Providing effective nutritional rehabilitation to patients hospitalised with anorexia nervosa (AN) is challenging, partly due to conservative recommendations that advocate feeding patients at low energy intakes. An 'underfeeding syndrome' can develop when patients are not provided with adequate nutrition during treatment, whereby malnourished patients fail to restore weight in a timely matter, and even lose weight. Of particular concern, the reintroduction of carbohydrate in a starved patient can increase the risk of developing electrolyte, metabolic and organ dysfunction. The proposed trial assesses the efficacy and safety of a lower carbohydrate enteral formula (28% carbohydrate) against a standard enteral formula (54% carbohydrate), in adolescent and young adult patients (aged 15-25 years), hospitalised with AN.

Original language	English
Article number	e038242
Number of pages	6
Journal	BMJ Open
Volume	10
Issue number	10
DOIs	https://doi.org/10.1136/bmjopen-2020-038242
Publication status	Published - 2020

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Parker, E., Flood, V., Halaki, M., Wearne, C., Anderson, G., Gomes, L., Clarke, S., Wilson, F., Russell, J., Frig, E., & Kohn, M. (2020). Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa. BMJ Open, 10(10), Article e038242. https://doi.org/10.1136/bmjopen-2020-038242

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title = "Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa",

abstract = "Providing effective nutritional rehabilitation to patients hospitalised with anorexia nervosa (AN) is challenging, partly due to conservative recommendations that advocate feeding patients at low energy intakes. An 'underfeeding syndrome' can develop when patients are not provided with adequate nutrition during treatment, whereby malnourished patients fail to restore weight in a timely matter, and even lose weight. Of particular concern, the reintroduction of carbohydrate in a starved patient can increase the risk of developing electrolyte, metabolic and organ dysfunction. The proposed trial assesses the efficacy and safety of a lower carbohydrate enteral formula (28% carbohydrate) against a standard enteral formula (54% carbohydrate), in adolescent and young adult patients (aged 15-25 years), hospitalised with AN.",

author = "E. Parker and V. Flood and M. Halaki and Christine Wearne and G. Anderson and L. Gomes and S. Clarke and F. Wilson and J. Russell and E. Frig and Michael Kohn",

year = "2020",

doi = "10.1136/bmjopen-2020-038242",

language = "English",

volume = "10",

journal = "BMJ Open",

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publisher = "BMJ Group",

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Parker, E, Flood, V, Halaki, M, Wearne, C, Anderson, G, Gomes, L, Clarke, S, Wilson, F, Russell, J, Frig, E & Kohn, M 2020, 'Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa', BMJ Open, vol. 10, no. 10, e038242. https://doi.org/10.1136/bmjopen-2020-038242

Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa. / Parker, E.; Flood, V.; Halaki, M. et al.
In: BMJ Open, Vol. 10, No. 10, e038242, 2020.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa

AU - Parker, E.

AU - Flood, V.

AU - Halaki, M.

AU - Wearne, Christine

AU - Anderson, G.

AU - Gomes, L.

AU - Clarke, S.

AU - Wilson, F.

AU - Russell, J.

AU - Frig, E.

AU - Kohn, Michael

PY - 2020

Y1 - 2020

N2 - Providing effective nutritional rehabilitation to patients hospitalised with anorexia nervosa (AN) is challenging, partly due to conservative recommendations that advocate feeding patients at low energy intakes. An 'underfeeding syndrome' can develop when patients are not provided with adequate nutrition during treatment, whereby malnourished patients fail to restore weight in a timely matter, and even lose weight. Of particular concern, the reintroduction of carbohydrate in a starved patient can increase the risk of developing electrolyte, metabolic and organ dysfunction. The proposed trial assesses the efficacy and safety of a lower carbohydrate enteral formula (28% carbohydrate) against a standard enteral formula (54% carbohydrate), in adolescent and young adult patients (aged 15-25 years), hospitalised with AN.

AB - Providing effective nutritional rehabilitation to patients hospitalised with anorexia nervosa (AN) is challenging, partly due to conservative recommendations that advocate feeding patients at low energy intakes. An 'underfeeding syndrome' can develop when patients are not provided with adequate nutrition during treatment, whereby malnourished patients fail to restore weight in a timely matter, and even lose weight. Of particular concern, the reintroduction of carbohydrate in a starved patient can increase the risk of developing electrolyte, metabolic and organ dysfunction. The proposed trial assesses the efficacy and safety of a lower carbohydrate enteral formula (28% carbohydrate) against a standard enteral formula (54% carbohydrate), in adolescent and young adult patients (aged 15-25 years), hospitalised with AN.

UR - https://hdl.handle.net/1959.7/uws:76583

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DO - 10.1136/bmjopen-2020-038242

M3 - Article

SN - 2044-6055

VL - 10

JO - BMJ Open

JF - BMJ Open

IS - 10

M1 - e038242

ER -

Study protocol for a randomised controlled trial investigating two different refeeding formulations to improve safety and efficacy of hospital management of adolescent and young adults admitted with anorexia nervosa

Abstract

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