Successful live birth following a short course of glucocorticoid suppression in a patient with autoimmune polyglandular syndrome type 2 and premature ovarian insufficiency: a case report

Rachel Bradbury; Mark McLean; Howard Smith

doi:10.1111/jog.15684

Successful live birth following a short course of glucocorticoid suppression in a patient with autoimmune polyglandular syndrome type 2 and premature ovarian insufficiency: a case report

Rachel Bradbury, Mark McLean, Howard Smith

Research output: Contribution to journal › Article › peer-review

Abstract

A 32-year-old nulliparous woman with premature ovarian insufficiency POI and autoimmune polyglandular syndrome type 2 (APS-2), presented to our fertility center with a 2.5-year history of amenorrhoea. Controlled ovarian hyperstimulation (COH), with high dose gonadotropins, failed to promote antral follicle growth. The patient was given a short, 4-week course of 2 mg dexamethasone prior to a repeat COH cycle, which resulted in the retrieval of good oocyte numbers and eventual live birth from a thawed embryo transfer.

Original language	English
Pages (from-to)	2194-2198
Number of pages	5
Journal	Journal of Obstetrics and Gynaecology Research
Volume	49
Issue number	8
DOIs	https://doi.org/10.1111/jog.15684
Publication status	Published - Aug 2023
Externally published	Yes

Keywords

Addison's disease
autoimmune oophoritis
glucocorticoids
primary ovarian insufficiency

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10.1111/jog.15684

Cite this

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abstract = "A 32-year-old nulliparous woman with premature ovarian insufficiency POI and autoimmune polyglandular syndrome type 2 (APS-2), presented to our fertility center with a 2.5-year history of amenorrhoea. Controlled ovarian hyperstimulation (COH), with high dose gonadotropins, failed to promote antral follicle growth. The patient was given a short, 4-week course of 2 mg dexamethasone prior to a repeat COH cycle, which resulted in the retrieval of good oocyte numbers and eventual live birth from a thawed embryo transfer.",

keywords = "Addison's disease, autoimmune oophoritis, glucocorticoids, primary ovarian insufficiency",

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pages = "2194--2198",

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Successful live birth following a short course of glucocorticoid suppression in a patient with autoimmune polyglandular syndrome type 2 and premature ovarian insufficiency: a case report. / Bradbury, Rachel; McLean, Mark; Smith, Howard.
In: Journal of Obstetrics and Gynaecology Research, Vol. 49, No. 8, 08.2023, p. 2194-2198.

Research output: Contribution to journal › Article › peer-review

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T1 - Successful live birth following a short course of glucocorticoid suppression in a patient with autoimmune polyglandular syndrome type 2 and premature ovarian insufficiency

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AU - McLean, Mark

AU - Smith, Howard

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N2 - A 32-year-old nulliparous woman with premature ovarian insufficiency POI and autoimmune polyglandular syndrome type 2 (APS-2), presented to our fertility center with a 2.5-year history of amenorrhoea. Controlled ovarian hyperstimulation (COH), with high dose gonadotropins, failed to promote antral follicle growth. The patient was given a short, 4-week course of 2 mg dexamethasone prior to a repeat COH cycle, which resulted in the retrieval of good oocyte numbers and eventual live birth from a thawed embryo transfer.

AB - A 32-year-old nulliparous woman with premature ovarian insufficiency POI and autoimmune polyglandular syndrome type 2 (APS-2), presented to our fertility center with a 2.5-year history of amenorrhoea. Controlled ovarian hyperstimulation (COH), with high dose gonadotropins, failed to promote antral follicle growth. The patient was given a short, 4-week course of 2 mg dexamethasone prior to a repeat COH cycle, which resulted in the retrieval of good oocyte numbers and eventual live birth from a thawed embryo transfer.

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KW - autoimmune oophoritis

KW - glucocorticoids

KW - primary ovarian insufficiency

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Successful live birth following a short course of glucocorticoid suppression in a patient with autoimmune polyglandular syndrome type 2 and premature ovarian insufficiency: a case report

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Keywords

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