Symmetrical dinuclear complexes with high DNA affinity based on [Ru(dpq)2(phen)]2+

Janice R. Aldrich-Wright, Craig R. Brodie, Edith C. Glazer, Nathan W. Luedtke, Lev Elson-Schwab, Yitzhak Tor

    Research output: Contribution to journalArticle

    51 Citations (Scopus)

    Abstract

    Symmetrical homometallic dinuclear complexes of the type [{Ru(dpq)â‚‚}â‚‚(phenââ"šÂ¬Ã¢â‚¬Å“SOSââ"šÂ¬Ã¢â‚¬Å“phen)]â´âº, with a flexible 2-mercaptoethyl ether linker joining the two [Ru(dpq)â‚‚(phen)]ÂÃ"šÃ‚²Ã¢Âº-based sub-units, have DNA dissociation constants (Kd) in the nM range.
    Original languageEnglish
    Number of pages2
    JournalChemical Communications
    Publication statusPublished - 2004

    Keywords

    • DNA probes
    • DNA-ligand interactions
    • Ruthenium compounds

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