TY - JOUR
T1 - Synthesis and characterization of polyethylene glycols conjugated to polybutylcyanoacrylate nanoparticles
AU - Babaei, Faezeh
AU - Alavi, Seyed Ebrahim
AU - Shahmabadi, Hasan Ebrahimi
AU - Akbarzadeh, Azim
PY - 2017
Y1 - 2017
N2 - This study aimed to evaluate the cytotoxicity effects of various polyethylene glycols (PEGs), and construction and characterization of polybutylcyanoacrylate (PBCA) nanoparticles. Cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on rat glioma C6 cell line, and PBCA nanoparticles were prepared by emulsion polymerization method. Also, the nanoparticles were characterized by dynamic light scattering and scanning electron microscopy. The findings showed that PEGs were approximately safe and cytotoxicity was inversely proportional with their molecular weights. In addition, the size of nanoparticles were increased with reducing molecular weights of PEGs. PEGs with negligible cytotoxicity and stabilizing functionality were demonstrated in this study.
AB - This study aimed to evaluate the cytotoxicity effects of various polyethylene glycols (PEGs), and construction and characterization of polybutylcyanoacrylate (PBCA) nanoparticles. Cytotoxicity was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay on rat glioma C6 cell line, and PBCA nanoparticles were prepared by emulsion polymerization method. Also, the nanoparticles were characterized by dynamic light scattering and scanning electron microscopy. The findings showed that PEGs were approximately safe and cytotoxicity was inversely proportional with their molecular weights. In addition, the size of nanoparticles were increased with reducing molecular weights of PEGs. PEGs with negligible cytotoxicity and stabilizing functionality were demonstrated in this study.
UR - http://hdl.handle.net/1959.7/uws:61242
U2 - 10.1080/00914037.2016.1263953
DO - 10.1080/00914037.2016.1263953
M3 - Article
SN - 1563-535X
VL - 66
SP - 738
EP - 741
JO - International Journal of Polymeric Materials and Polymeric Biomaterials
JF - International Journal of Polymeric Materials and Polymeric Biomaterials
IS - 14
ER -