Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

K. Benjamin Garbutcheon-Singh; Markus Galanski; Bernhard K. Keppler; Janice R. Aldrich-Wright

doi:10.1016/j.ica.2015.10.048

Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

K. Benjamin Garbutcheon-Singh, Markus Galanski, Bernhard K. Keppler, Janice R. Aldrich-Wright

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We have synthesised, characterised and examined the cytotoxicity of [(1,10- phenanthroline)(1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)]2+ (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 Â± 0.00 μM, comparable with that of [(1,10-phenanthroline)(1R,2R-diaminocyclohexane) platinum(II)]2+ (1.5 Â± 0.14 μM) but less cytotoxic than [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2+(0.15 Â± 0.06 μM) and cisplatin (0.43 Â± 0.06 μM).

Original language	English
Pages (from-to)	152-156
Number of pages	5
Journal	Inorganica Chimica Acta
Volume	441
DOIs	https://doi.org/10.1016/j.ica.2015.10.048
Publication status	Published - 2016

Keywords

cytotoxicity
leukemia
platinum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{2d8b08d4396343d58e7676ae71497156,

title = "Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)",

abstract = "We have synthesised, characterised and examined the cytotoxicity of [(1,10- phenanthroline)(1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)]2+ (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 {\^A}± 0.00 μM, comparable with that of [(1,10-phenanthroline)(1R,2R-diaminocyclohexane) platinum(II)]2+ (1.5 {\^A}± 0.14 μM) but less cytotoxic than [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2+(0.15 {\^A}± 0.06 μM) and cisplatin (0.43 {\^A}± 0.06 μM).",

keywords = "cytotoxicity, leukemia, platinum",

author = "Garbutcheon-Singh, {K. Benjamin} and Markus Galanski and Keppler, {Bernhard K.} and Aldrich-Wright, {Janice R.}",

year = "2016",

doi = "10.1016/j.ica.2015.10.048",

language = "English",

volume = "441",

pages = "152--156",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier",

}

TY - JOUR

T1 - Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

AU - Garbutcheon-Singh, K. Benjamin

AU - Galanski, Markus

AU - Keppler, Bernhard K.

AU - Aldrich-Wright, Janice R.

PY - 2016

Y1 - 2016

N2 - We have synthesised, characterised and examined the cytotoxicity of [(1,10- phenanthroline)(1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)]2+ (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 Â± 0.00 μM, comparable with that of [(1,10-phenanthroline)(1R,2R-diaminocyclohexane) platinum(II)]2+ (1.5 Â± 0.14 μM) but less cytotoxic than [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2+(0.15 Â± 0.06 μM) and cisplatin (0.43 Â± 0.06 μM).

AB - We have synthesised, characterised and examined the cytotoxicity of [(1,10- phenanthroline)(1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)]2+ (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 Â± 0.00 μM, comparable with that of [(1,10-phenanthroline)(1R,2R-diaminocyclohexane) platinum(II)]2+ (1.5 Â± 0.14 μM) but less cytotoxic than [(1,10-phenanthroline)(1S,2S-diaminocyclohexane)platinum(II)]2+(0.15 Â± 0.06 μM) and cisplatin (0.43 Â± 0.06 μM).

KW - cytotoxicity

KW - leukemia

KW - platinum

UR - http://handle.uws.edu.au:8081/1959.7/uws:32716

U2 - 10.1016/j.ica.2015.10.048

DO - 10.1016/j.ica.2015.10.048

M3 - Article

SN - 0020-1693

VL - 441

SP - 152

EP - 156

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

Abstract

Keywords

UN SDGs

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