Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

K. Benjamin Garbutcheon-Singh; Mathea S. Galanski; Bernhard K. Keppler; Janice R. Aldrich-Wright

doi:10.1016/j.ica.2015.10.048

Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

K. Benjamin Garbutcheon-Singh
, Mathea S. Galanski
, Bernhard K. Keppler
, Janice R. Aldrich-Wright

School of Science

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We have synthesised, characterised and examined the cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)](2+) (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 +/- 0.00 mu M, comparable with that of [(1,10-phenanthroline)(1R, 2R-diaminocyclohexane) platinum (II)](2+) (1.5 +/- 0.14 mu M) but less cytotoxic than [(1,10-phenanthroline)(1S, 2S-diaminocyclohexane) platinum( II)](2+) (0.10 +/- 0.06 mu M) and cisplatin (0.43 +/- 0.06 mu M). +/- 2015 Elsevier B. V. All rights reserved.

Original language	English
Pages (from-to)	152-156
Number of pages	5
Journal	Inorganica Chimica Acta
Volume	441
DOIs	https://doi.org/10.1016/j.ica.2015.10.048
Publication status	Published - 2016

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

(1R,2R,4R/1S, 2S,4S)-4-methyl-1,2-cyclohexanediamine
1,10-Phenathroline
Cytotoxicity
Platinum

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10.1016/j.ica.2015.10.048

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@article{2d8b08d4396343d58e7676ae71497156,

title = "Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)",

abstract = "We have synthesised, characterised and examined the cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)](2+) (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 +/- 0.00 mu M, comparable with that of [(1,10-phenanthroline)(1R, 2R-diaminocyclohexane) platinum (II)](2+) (1.5 +/- 0.14 mu M) but less cytotoxic than [(1,10-phenanthroline)(1S, 2S-diaminocyclohexane) platinum( II)](2+) (0.10 +/- 0.06 mu M) and cisplatin (0.43 +/- 0.06 mu M). +/- 2015 Elsevier B. V. All rights reserved.",

keywords = "(1R,2R,4R/1S, 2S,4S)-4-methyl-1,2-cyclohexanediamine, 1,10-Phenathroline, Cytotoxicity, Platinum",

author = "Garbutcheon-Singh, \{K. Benjamin\} and Galanski, \{Mathea S.\} and Keppler, \{Bernhard K.\} and Aldrich-Wright, \{Janice R.\}",

year = "2016",

doi = "10.1016/j.ica.2015.10.048",

language = "English",

volume = "441",

pages = "152--156",

journal = "Inorganica Chimica Acta",

issn = "0020-1693",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

AU - Garbutcheon-Singh, K. Benjamin

AU - Galanski, Mathea S.

AU - Keppler, Bernhard K.

AU - Aldrich-Wright, Janice R.

PY - 2016

Y1 - 2016

N2 - We have synthesised, characterised and examined the cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)](2+) (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 +/- 0.00 mu M, comparable with that of [(1,10-phenanthroline)(1R, 2R-diaminocyclohexane) platinum (II)](2+) (1.5 +/- 0.14 mu M) but less cytotoxic than [(1,10-phenanthroline)(1S, 2S-diaminocyclohexane) platinum( II)](2+) (0.10 +/- 0.06 mu M) and cisplatin (0.43 +/- 0.06 mu M). +/- 2015 Elsevier B. V. All rights reserved.

AB - We have synthesised, characterised and examined the cytotoxicity of [(1,10-phenanthroline) (1R,2R,4R/1S,2S,4S-4-methyl-cyclohexanediamine) platinum(II)](2+) (PHEN-4-MeDACH) in the L1210 cell line. The cytotoxicity of PHEN-4-MeDACH in the murine leukaemia (L12010) cell line was 1.8 +/- 0.00 mu M, comparable with that of [(1,10-phenanthroline)(1R, 2R-diaminocyclohexane) platinum (II)](2+) (1.5 +/- 0.14 mu M) but less cytotoxic than [(1,10-phenanthroline)(1S, 2S-diaminocyclohexane) platinum( II)](2+) (0.10 +/- 0.06 mu M) and cisplatin (0.43 +/- 0.06 mu M). +/- 2015 Elsevier B. V. All rights reserved.

KW - (1R,2R,4R/1S, 2S,4S)-4-methyl-1,2-cyclohexanediamine

KW - 1,10-Phenathroline

KW - Cytotoxicity

KW - Platinum

UR - http://handle.uws.edu.au:8081/1959.7/uws:32716

U2 - 10.1016/j.ica.2015.10.048

DO - 10.1016/j.ica.2015.10.048

M3 - Article

SN - 0020-1693

VL - 441

SP - 152

EP - 156

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

ER -

Synthesis, characterisation and cytotoxicity of [(1,10-phenanthroline)(1R,2R,4R/1S,2S,4S)-4-methyl-1,2-cyclohexanediamine)platinum(II)]2+ (PHEN-4-MeDACH)

Abstract

UN SDGs

Keywords

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