Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester

Sarah J. Yousouf; Craig R. Brodie; Nial J. Wheate; Janice R. Aldrich-Wright

Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester

Sarah J. Yousouf, Craig R. Brodie, Nial J. Wheate, Janice R. Aldrich-Wright

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Abstract

A potential anticancer heterodinuclear ruthenium(II)ÃƒÂ¢Ã¢"šÂ¬Ã¢â‚¬Å“platinum(II) complex, [ruthenium(II)(4,4ÃƒÂ¢Ã¢"šÂ¬Ã‚Â²-dimethyl-2,2ÃƒÂ¢Ã¢"šÂ¬Ã‚Â²-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their ÃƒÅ½Ã¢â‚¬Â- and ÃƒÅ½Ã¢â‚¬Âº-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UVÃƒÂ¢Ã¢"šÂ¬Ã¢â‚¬Å“Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

Original language	English
Number of pages	11
Journal	Polyhedron
Publication status	Published - 2007

Keywords

anticancer
heterodinuclear
l-Cysteine methyl ester
phenanthroline
platinum(II)
ruthenium(II)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester",

abstract = "A potential anticancer heterodinuclear ruthenium(II){\~A}ƒ{\^A}¢{\~A}¢{"}{\v s}{\^A}¬{\~A}¢{\^a}‚¬{\AA}“platinum(II) complex, [ruthenium(II)(4,4{\~A}ƒ{\^A}¢{\~A}¢{"}{\v s}{\^A}¬{\~A}‚{\^A}²-dimethyl-2,2{\~A}ƒ{\^A}¢{\~A}¢{"}{\v s}{\^A}¬{\~A}‚{\^A}²-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their {\~A}ƒ{\AA}½{\~A}¢{\^a}‚¬{\^A}- and {\~A}ƒ{\AA}½{\~A}¢{\^a}‚¬{\^A}º-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV{\~A}ƒ{\^A}¢{\~A}¢{"}{\v s}{\^A}¬{\~A}¢{\^a}‚¬{\AA}“Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.",

keywords = "anticancer, heterodinuclear, l-Cysteine methyl ester, phenanthroline, platinum(II), ruthenium(II)",

author = "Yousouf, {Sarah J.} and Brodie, {Craig R.} and Wheate, {Nial J.} and Aldrich-Wright, {Janice R.}",

year = "2007",

language = "English",

journal = "Polyhedron",

issn = "0277-5387",

publisher = "Elsevier",

}

TY - JOUR

T1 - Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester

AU - Yousouf, Sarah J.

AU - Brodie, Craig R.

AU - Wheate, Nial J.

AU - Aldrich-Wright, Janice R.

PY - 2007

Y1 - 2007

N2 - A potential anticancer heterodinuclear ruthenium(II)ÃƒÂ¢Ã¢"šÂ¬Ã¢â‚¬Å“platinum(II) complex, [ruthenium(II)(4,4ÃƒÂ¢Ã¢"šÂ¬Ã‚Â²-dimethyl-2,2ÃƒÂ¢Ã¢"šÂ¬Ã‚Â²-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their ÃƒÅ½Ã¢â‚¬Â- and ÃƒÅ½Ã¢â‚¬Âº-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UVÃƒÂ¢Ã¢"šÂ¬Ã¢â‚¬Å“Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

AB - A potential anticancer heterodinuclear ruthenium(II)ÃƒÂ¢Ã¢"šÂ¬Ã¢â‚¬Å“platinum(II) complex, [ruthenium(II)(4,4ÃƒÂ¢Ã¢"šÂ¬Ã‚Â²-dimethyl-2,2ÃƒÂ¢Ã¢"šÂ¬Ã‚Â²-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their ÃƒÅ½Ã¢â‚¬Â- and ÃƒÅ½Ã¢â‚¬Âº-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UVÃƒÂ¢Ã¢"šÂ¬Ã¢â‚¬Å“Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.

KW - anticancer

KW - heterodinuclear

KW - l-Cysteine methyl ester

KW - phenanthroline

KW - platinum(II)

KW - ruthenium(II)

UR - http://handle.uws.edu.au:8081/1959.7/34904

M3 - Article

SN - 0277-5387

JO - Polyhedron

JF - Polyhedron

ER -

Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester

Abstract

Keywords

UN SDGs

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