TY - JOUR
T1 - Synthesis of a heterodinuclear ruthenium(II)-platinum(II) complex linked by L-cysteine methyl ester
AU - Yousouf, Sarah J.
AU - Brodie, Craig R.
AU - Wheate, Nial J.
AU - Aldrich-Wright, Janice R.
PY - 2007
Y1 - 2007
N2 - A potential anticancer heterodinuclear ruthenium(II)–platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their ÃŽâ€- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV–Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.
AB - A potential anticancer heterodinuclear ruthenium(II)–platinum(II) complex, [ruthenium(II)(4,4′-dimethyl-2,2′-bipyridine)2(5-(l-cysteine-methyl ester)-1,10-phenanthroline)-trans-chlorodiammineplatinum(II)] chloride, [Ru(Me2bipy)2(5-(l-cysteine-Me)-phen)-trans-Pt(NH3)2Cl]Cl3, was synthesised. l-Cysteine methyl ester was used to link the two metal centres, as more conventional straight chain diaminoalkanes and 2-mercaptoethylamine failed to couple to the phenanthroline ligand. From the precursor mononuclear ruthenium(II) complexes, which were separated into their ÃŽâ€- and Λ-isomers by column chromatography, the dinuclear complex was synthesised and characterised by 1H and 13C NMR, UV–Vis, circular dichroism, fluorescence and electrospray ionisation mass spectrometry.
KW - anticancer
KW - heterodinuclear
KW - l-Cysteine methyl ester
KW - phenanthroline
KW - platinum(II)
KW - ruthenium(II)
UR - http://handle.uws.edu.au:8081/1959.7/34904
M3 - Article
SN - 0277-5387
JO - Polyhedron
JF - Polyhedron
ER -
