TY - JOUR
T1 - Synthesis of water-soluble prodrugs of the cytotoxic agent Combretastatin A4
AU - Bedford, Simon B.
AU - Quarterman, Charmaine P.
AU - Rathbone, Daniel L.
AU - Slack, John A.
AU - Griffin, Roger J.
AU - Stevens, Malcolm F. G.
PY - 1996
Y1 - 1996
N2 - Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 (1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase.
AB - Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 (1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase.
KW - alkaline phosphatase
KW - antineoplastic agents
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:47704
U2 - 10.1016/0960-894X(95)00580-M
DO - 10.1016/0960-894X(95)00580-M
M3 - Article
SN - 0960-894X
VL - 6
SP - 157
EP - 160
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 2
ER -