Synthetic corneal inlays : invited review

Deborah F. Sweeney; Antti Vannas; Timothy C. Hughes; Margaret D. M. Evans; Keith M. McLean; Ruo Zhong Xie; V. K. Pravin; Ruby Kala Prakasam

doi:10.1111/j.1444-0938.2007.00198.x

Synthetic corneal inlays : invited review

Deborah F. Sweeney, Antti Vannas, Timothy C. Hughes, Margaret D. M. Evans, Keith M. McLean, Ruo Zhong Xie, V. K. Pravin, Ruby Kala Prakasam

Research output: Contribution to journal › Article › peer-review

Abstract

This review is based on the activities of the Vision Cooperative Research Centre (previously Cooperative Research Centre for Eye Research and Technology) Corneal Implant team from 1991 to 2007. The development of a synthetic polymer of perfluoropolyether (PFPE), meeting essential physical and biological requirements, for use as a corneal inlay is presented. Each inlay was placed in a corneal flap created with a microkeratome and monitored over a two-year period in a rabbit model. The results indicate that the PFPE implant shows excellent biocompatibility and biostability. As a result, a Phase 1 clinical trial is being conducted. Three years post-implantation, the PFPE inlays are exhibiting continued excellent biocompatibility. Corneal inlays made from PFPE are biocompatible with corneal tissue in the long term and offer a safe and biologically-acceptable alternative to other forms of refractive surgery.

Original language	English
Pages (from-to)	56-66
Number of pages	11
Journal	Clinical and Experimental Optometry
Volume	91
Issue number	1
DOIs	https://doi.org/10.1111/j.1444-0938.2007.00198.x
Publication status	Published - 2008

Keywords

artificial corneas
clinical trials

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10.1111/j.1444-0938.2007.00198.x

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title = "Synthetic corneal inlays : invited review",

abstract = "This review is based on the activities of the Vision Cooperative Research Centre (previously Cooperative Research Centre for Eye Research and Technology) Corneal Implant team from 1991 to 2007. The development of a synthetic polymer of perfluoropolyether (PFPE), meeting essential physical and biological requirements, for use as a corneal inlay is presented. Each inlay was placed in a corneal flap created with a microkeratome and monitored over a two-year period in a rabbit model. The results indicate that the PFPE implant shows excellent biocompatibility and biostability. As a result, a Phase 1 clinical trial is being conducted. Three years post-implantation, the PFPE inlays are exhibiting continued excellent biocompatibility. Corneal inlays made from PFPE are biocompatible with corneal tissue in the long term and offer a safe and biologically-acceptable alternative to other forms of refractive surgery.",

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AU - Sweeney, Deborah F.

AU - Vannas, Antti

AU - Hughes, Timothy C.

AU - Evans, Margaret D. M.

AU - McLean, Keith M.

AU - Xie, Ruo Zhong

AU - Pravin, V. K.

AU - Prakasam, Ruby Kala

PY - 2008

Y1 - 2008

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AB - This review is based on the activities of the Vision Cooperative Research Centre (previously Cooperative Research Centre for Eye Research and Technology) Corneal Implant team from 1991 to 2007. The development of a synthetic polymer of perfluoropolyether (PFPE), meeting essential physical and biological requirements, for use as a corneal inlay is presented. Each inlay was placed in a corneal flap created with a microkeratome and monitored over a two-year period in a rabbit model. The results indicate that the PFPE implant shows excellent biocompatibility and biostability. As a result, a Phase 1 clinical trial is being conducted. Three years post-implantation, the PFPE inlays are exhibiting continued excellent biocompatibility. Corneal inlays made from PFPE are biocompatible with corneal tissue in the long term and offer a safe and biologically-acceptable alternative to other forms of refractive surgery.

KW - artificial corneas

KW - clinical trials

UR - http://handle.uws.edu.au:8081/1959.7/550568

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JO - Clinical and Experimental Optometry

JF - Clinical and Experimental Optometry

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Synthetic corneal inlays : invited review

Abstract

Keywords

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