Systemic α-particles are likely to yield more important advances in radiotherapy than are protons

New treatment modalities aimed at increasing tumor control and decreasing complications include proton and heavy ion external beam radiotherapies and systemic targeted alphaparticle therapy (TAT). Although proton therapy (PT) has received the most press recently, some would argue that systemic α-particles are likely to yield more important advances than are protons. This is the claim debated in this month's Point/Counterpoint.