Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

Xi-Yong Yu; Shu-Guang Lin; Zhi-Wei Zhou; Xiao Chen; Jun Liang; Wei Duan; Xue-Qing Yu; Jing-Yuan Wen; Balram Chowbay; Chun Guang Li; Fwu-Shan Sheu; Eli Chan; Shu-Feng Zhou

doi:10.1016/j.neulet.2007.02.079

Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

Xi-Yong Yu, Shu-Guang Lin, Zhi-Wei Zhou, Xiao Chen, Jun Liang, Wei Duan, Xue-Qing Yu, Jing-Yuan Wen, Balram Chowbay, Chun Guang Li, Fwu-Shan Sheu, Eli Chan, Shu-Feng Zhou

NICM Health Research Institute

Research output: Contribution to journal › Article › peer-review

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Abstract

Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.

Original language	English
Pages (from-to)	261-265
Number of pages	5
Journal	Neuroscience Letters
Volume	417
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2007.02.079
Publication status	Published - 2007

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Yu, X.-Y., Lin, S.-G., Zhou, Z.-W., Chen, X., Liang, J., Duan, W., Yu, X.-Q., Wen, J.-Y., Chowbay, B., Li, C. G., Sheu, F.-S., Chan, E., & Zhou, S.-F. (2007). Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats. Neuroscience Letters, 417(3), 261-265. https://doi.org/10.1016/j.neulet.2007.02.079

@article{ac8a0ede08fc4e71af57c6511859664e,

title = "Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats",

abstract = "Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.",

author = "Xi-Yong Yu and Shu-Guang Lin and Zhi-Wei Zhou and Xiao Chen and Jun Liang and Wei Duan and Xue-Qing Yu and Jing-Yuan Wen and Balram Chowbay and Li, {Chun Guang} and Fwu-Shan Sheu and Eli Chan and Shu-Feng Zhou",

year = "2007",

doi = "10.1016/j.neulet.2007.02.079",

language = "English",

volume = "417",

pages = "261--265",

journal = "Neuroscience Letters",

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TY - JOUR

T1 - Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

AU - Yu, Xi-Yong

AU - Lin, Shu-Guang

AU - Zhou, Zhi-Wei

AU - Chen, Xiao

AU - Liang, Jun

AU - Duan, Wei

AU - Yu, Xue-Qing

AU - Wen, Jing-Yuan

AU - Chowbay, Balram

AU - Li, Chun Guang

AU - Sheu, Fwu-Shan

AU - Chan, Eli

AU - Zhou, Shu-Feng

PY - 2007

Y1 - 2007

N2 - Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.

AB - Tanshinone IIB (TSB) is a major active constituent of the root of Salvia miltiorrhiza (Danshen) used in the treatment of acute stroke. Danshen extracts and TSB have shown marked neuron-protective effects in mouse studies but there is a lack of clinical evidence for the neuron-protective effects of Danshen and its active ingredients. This study investigated the neuron-protective effects of TSB in experimentally stroked rats. TSB at 5 and 25 mg/kg by intraperitoneal injection significantly reduced the focal infarct volume, cerebral histological damage and apoptosis in rats subjected to middle cerebral artery occlusion (MCAO) compared to MCAO rats receiving vehicle. This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB.

UR - http://handle.uws.edu.au:8081/1959.7/532391

U2 - 10.1016/j.neulet.2007.02.079

DO - 10.1016/j.neulet.2007.02.079

M3 - Article

C2 - 17397998

SN - 0304-3940

VL - 417

SP - 261

EP - 265

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats

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