Targets for medical therapy to limit abdominal aortic aneurysm progression

Theophilus I. Emeto, Sai-Wang Seto, Jonathan Golledge

    Research output: Contribution to journalArticlepeer-review

    21 Citations (Scopus)

    Abstract

    Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Most AAAs are asymptomatic and screening programs have been introduced to identify AAAs at an early stage in some countries. There is currently no accepted therapy for early stage or small AAAs, which are frequently identified by such programs. In this review, we discuss work underway to identify targets for medical treatments to limit progression of small AAAs. Specifically we discuss studies, which have examined the potential of targeting inflammation, proteolysis, the renin-angiotensin system, the coagulation system and sex hormones as approaches to limiting AAA pathogenesis. As yet, none of the treatment targets have translated into an agent, which can effectively reduce AAA progression in clinical practice.
    Original languageEnglish
    Pages (from-to)860-873
    Number of pages14
    JournalCurrent Drug Targets
    Volume15
    Issue number9
    DOIs
    Publication statusPublished - 2014

    Keywords

    • abdominal aortic aneurysms
    • aneurysms
    • animal models
    • pharmacotherapy

    Fingerprint

    Dive into the research topics of 'Targets for medical therapy to limit abdominal aortic aneurysm progression'. Together they form a unique fingerprint.

    Cite this