Ternstroenol F : a new pentacyclic triterpenoid saponin isolated from the Australian rainforest plant Ternstroemia cherryi

Ritesh Raju; Shintu Mathew; Paul Reddell; Gerald Munch

doi:10.1080/14786419.2022.2039139

Ternstroenol F : a new pentacyclic triterpenoid saponin isolated from the Australian rainforest plant Ternstroemia cherryi

Ritesh Raju
, Shintu Mathew
, Paul Reddell
, Gerald Munch

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

A detailed close phytochemical investigation of the fruits of Ternstroemia cherryi led to the isolation and identification of the minor metabolite, ternstroenol F, which possessed the usual barrigenol-like terpenoid backbone. The notable difference was that this minor metabolite had the 2(E)-4(Z)-6(E)-decatrienoic acid forming an ester bond at C-22 of the oleanane backbone. Ternstroenol F was evaluated for its inhibitory effects on NO inhibition, cell viability and TNF- α release in RAW 264.7 macrophages, displaying an IC₅₀ values of 0.23, 0.81 and 1.84 µM respectively.

Original language	English
Pages (from-to)	2421-2426
Number of pages	6
Journal	Natural Product Research
Volume	37
Issue number	14
DOIs	https://doi.org/10.1080/14786419.2022.2039139
Publication status	Published - 2023

Bibliographical note

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

Open Access - Access Right Statement

© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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10.1080/14786419.2022.2039139

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title = "Ternstroenol F : a new pentacyclic triterpenoid saponin isolated from the Australian rainforest plant Ternstroemia cherryi",

abstract = "A detailed close phytochemical investigation of the fruits of Ternstroemia cherryi led to the isolation and identification of the minor metabolite, ternstroenol F, which possessed the usual barrigenol-like terpenoid backbone. The notable difference was that this minor metabolite had the 2(E)-4(Z)-6(E)-decatrienoic acid forming an ester bond at C-22 of the oleanane backbone. Ternstroenol F was evaluated for its inhibitory effects on NO inhibition, cell viability and TNF- α release in RAW 264.7 macrophages, displaying an IC50 values of 0.23, 0.81 and 1.84 µM respectively.",

author = "Ritesh Raju and Shintu Mathew and Paul Reddell and Gerald Munch",

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doi = "10.1080/14786419.2022.2039139",

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AU - Raju, Ritesh

AU - Mathew, Shintu

AU - Reddell, Paul

AU - Munch, Gerald

PY - 2023

Y1 - 2023

N2 - A detailed close phytochemical investigation of the fruits of Ternstroemia cherryi led to the isolation and identification of the minor metabolite, ternstroenol F, which possessed the usual barrigenol-like terpenoid backbone. The notable difference was that this minor metabolite had the 2(E)-4(Z)-6(E)-decatrienoic acid forming an ester bond at C-22 of the oleanane backbone. Ternstroenol F was evaluated for its inhibitory effects on NO inhibition, cell viability and TNF- α release in RAW 264.7 macrophages, displaying an IC50 values of 0.23, 0.81 and 1.84 µM respectively.

AB - A detailed close phytochemical investigation of the fruits of Ternstroemia cherryi led to the isolation and identification of the minor metabolite, ternstroenol F, which possessed the usual barrigenol-like terpenoid backbone. The notable difference was that this minor metabolite had the 2(E)-4(Z)-6(E)-decatrienoic acid forming an ester bond at C-22 of the oleanane backbone. Ternstroenol F was evaluated for its inhibitory effects on NO inhibition, cell viability and TNF- α release in RAW 264.7 macrophages, displaying an IC50 values of 0.23, 0.81 and 1.84 µM respectively.

UR - https://hdl.handle.net/1959.7/uws:62524

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JO - Natural Product Research

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IS - 14

ER -

Ternstroenol F : a new pentacyclic triterpenoid saponin isolated from the Australian rainforest plant Ternstroemia cherryi

Abstract

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