TY - JOUR
T1 - Terpyridineplatinum(II) incorporation in N-methylpyrrole-based polyamides by solid phase techniques
AU - Holst, Marcelis van
AU - Le Pevelen, Delphine
AU - Aldrich-Wright, Janice R.
PY - 2008
Y1 - 2008
N2 - The incorporation of terpyridineplatinum(II) centres into sequence-selective polyamides has been explored in this study, with the aim of producing cytotoxic molecules that display DNA sequence specificity. To facilitate this a terpyridineplatinum(II)-based metallointercalator has been developed, which can be incorporated into sequence-selective polyamides using standard machine-assisted peptide coupling techniques. A novel N-methylpyrrole-based metallopolyamide, containing the new terpyridineplatinum(II) moiety, was also synthesised to validate this new method of incorporation.
AB - The incorporation of terpyridineplatinum(II) centres into sequence-selective polyamides has been explored in this study, with the aim of producing cytotoxic molecules that display DNA sequence specificity. To facilitate this a terpyridineplatinum(II)-based metallointercalator has been developed, which can be incorporated into sequence-selective polyamides using standard machine-assisted peptide coupling techniques. A novel N-methylpyrrole-based metallopolyamide, containing the new terpyridineplatinum(II) moiety, was also synthesised to validate this new method of incorporation.
KW - antineoplastic agents
KW - metal complexes
KW - platinum
KW - polyamides
KW - pyridine
KW - solid-phase synthesis
UR - http://handle.uws.edu.au:8081/1959.7/45953
M3 - Article
SN - 1434-1948
JO - European Journal of Inorganic Chemistry
JF - European Journal of Inorganic Chemistry
ER -
