Terpyridineplatinum(II) incorporation in N-methylpyrrole-based polyamides by solid phase techniques

The incorporation of terpyridineplatinum(II) centres into sequence-selective polyamides has been explored in this study, with the aim of producing cytotoxic molecules that display DNA sequence specificity. To facilitate this a terpyridineplatinum(II)-based metallointercalator has been developed, which can be incorporated into sequence-selective polyamides using standard machine-assisted peptide coupling techniques. A novel N-methylpyrrole-based metallopolyamide, containing the new terpyridineplatinum(II) moiety, was also synthesised to validate this new method of incorporation.