TERT gene : its function and dysregulation in cancer

Andrew J. Colebatch; Alexander Dobrovic; Wendy A. Cooper

doi:10.1136/jclinpath-2018-205653

TERT gene : its function and dysregulation in cancer

Andrew J. Colebatch, Alexander Dobrovic, Wendy A. Cooper

Western Sydney University

Research output: Contribution to journal › Article › peer-review

71 Citations (Scopus)

Abstract

In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.

Original language	English
Pages (from-to)	281-284
Number of pages	4
Journal	Journal of Clinical Pathology
Volume	72
Issue number	4
DOIs	https://doi.org/10.1136/jclinpath-2018-205653
Publication status	Published - 2019

Keywords

cancer
cancer genetics
telomerase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1136/jclinpath-2018-205653

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title = "TERT gene : its function and dysregulation in cancer",

abstract = "In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.",

keywords = "cancer, cancer genetics, telomerase",

author = "Colebatch, {Andrew J.} and Alexander Dobrovic and Cooper, {Wendy A.}",

year = "2019",

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T1 - TERT gene : its function and dysregulation in cancer

AU - Colebatch, Andrew J.

AU - Dobrovic, Alexander

AU - Cooper, Wendy A.

PY - 2019

Y1 - 2019

N2 - In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.

AB - In this review, we summarise the function and structure of telomerase reverse transcriptase (TERT) in humans, including its regulation. The dysregulation of telomerase through TERT promoter mutations across a range of cancers is discussed. The molecular mechanism activated by TERT promoter mutations is outlined. Finally, the timing of TERT promoter mutations during carcinogenesis is reviewed in the context of their potential utility as clinical biomarkers of malignant transformation.

KW - cancer

KW - cancer genetics

KW - telomerase

UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:51125

U2 - 10.1136/jclinpath-2018-205653

DO - 10.1136/jclinpath-2018-205653

M3 - Article

SN - 0021-9746

VL - 72

SP - 281

EP - 284

JO - Journal of Clinical Pathology

JF - Journal of Clinical Pathology

IS - 4

ER -

TERT gene : its function and dysregulation in cancer

Abstract

Keywords

UN SDGs

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