The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria

Tina S. Skinner-Adams; Christopher L. Peatey; Karen Anderson; Katharine R. Trenholme; David Krige; Christopher L. Brown; Colin Stack; Desire M. M. Nsangou; Rency T. Mathews; Karine Thivierge; John P. Dalton; Donald L. Gardiner

doi:10.1128/AAC.06245-11

The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria

Tina S. Skinner-Adams, Christopher L. Peatey, Karen Anderson, Katharine R. Trenholme, David Krige, Christopher L. Brown, Colin Stack, Desire M. M. Nsangou, Rency T. Mathews, Karine Thivierge, John P. Dalton, Donald L. Gardiner

School of Science

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41 Citations (Scopus)

Abstract

Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria. Copyright Ã‚Â© 2012, American Society for Microbiology. All Rights Reserved.

Original language	English
Pages (from-to)	3244-3249
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	56
Issue number	6
DOIs	https://doi.org/10.1128/AAC.06245-11
Publication status	Published - 2012

Keywords

Plasmodium falciparum
amino acids
aminopeptidases
antimalarials
hemoglobin
malaria
murine malaria
plasmodium

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1128/AAC.06245-11

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Skinner-Adams, T. S., Peatey, C. L., Anderson, K., Trenholme, K. R., Krige, D., Brown, C. L., Stack, C., Nsangou, D. M. M., Mathews, R. T., Thivierge, K., Dalton, J. P., & Gardiner, D. L. (2012). The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria. Antimicrobial Agents and Chemotherapy, 56(6), 3244-3249. https://doi.org/10.1128/AAC.06245-11

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title = "The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria",

abstract = "Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria. Copyright {\~A}‚{\^A}{\textcopyright} 2012, American Society for Microbiology. All Rights Reserved.",

keywords = "Plasmodium falciparum, amino acids, aminopeptidases, antimalarials, hemoglobin, malaria, murine malaria, plasmodium",

author = "Skinner-Adams, {Tina S.} and Peatey, {Christopher L.} and Karen Anderson and Trenholme, {Katharine R.} and David Krige and Brown, {Christopher L.} and Colin Stack and Nsangou, {Desire M. M.} and Mathews, {Rency T.} and Karine Thivierge and Dalton, {John P.} and Gardiner, {Donald L.}",

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doi = "10.1128/AAC.06245-11",

language = "English",

volume = "56",

pages = "3244--3249",

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AU - Skinner-Adams, Tina S.

AU - Peatey, Christopher L.

AU - Anderson, Karen

AU - Trenholme, Katharine R.

AU - Krige, David

AU - Brown, Christopher L.

AU - Stack, Colin

AU - Nsangou, Desire M. M.

AU - Mathews, Rency T.

AU - Thivierge, Karine

AU - Dalton, John P.

AU - Gardiner, Donald L.

PY - 2012

Y1 - 2012

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AB - Malaria remains a significant risk in many areas of the world, with resistance to the current antimalarial pharmacopeia an everincreasing problem. The M1 alanine aminopeptidase (PfM1AAP) and M17 leucine aminopeptidase (PfM17LAP) are believed to play a role in the terminal stages of digestion of host hemoglobin and thereby generate a pool of free amino acids that are essential for parasite growth and development. Here, we show that an orally bioavailable aminopeptidase inhibitor, CHR-2863, is efficacious against murine malaria. Copyright Ã‚Â© 2012, American Society for Microbiology. All Rights Reserved.

KW - Plasmodium falciparum

KW - amino acids

KW - aminopeptidases

KW - antimalarials

KW - hemoglobin

KW - malaria

KW - murine malaria

KW - plasmodium

UR - http://handle.uws.edu.au:8081/1959.7/516855

U2 - 10.1128/AAC.06245-11

DO - 10.1128/AAC.06245-11

M3 - Article

C2 - 22450967

SN - 0066-4804

VL - 56

SP - 3244

EP - 3249

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 6

ER -

The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria

Abstract

Keywords

UN SDGs

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