The design of a new concept chromatography column

Michelle Camenzuli, Harald J. Ritchie, James R. Ladine, R. Andrew Shalliker

    Research output: Contribution to journalArticlepeer-review

    47 Citations (Scopus)

    Abstract

    Active Flow Management is a new separation technique whereby the flow of mobile phase and the injection of sample are introduced to the column in a manner that allows migration according to the principles of the infinite diameter column. A segmented flow outlet fitting allows for the separation of solvent or solute that elutes along the central radial section of the column from that of the sample or solvent that elutes along the wall region of the column. Separation efficiency on the analytical scale is increased by 25% with an increase in sensitivity by as much as 52% compared to conventional separations.
    Original languageEnglish
    Pages (from-to)5127-5130
    Number of pages4
    JournalAnalyst
    Volume136
    Issue number24
    DOIs
    Publication statusPublished - 2011

    Keywords

    • liquid chromatography
    • solvents

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