The effect of atypical cannabinoid compounds on skeletal muscle homeostasis in a diet induced obese rat model

Anna C. Simcocks; Lannie O'Keefe; Kayte A. Jenkin; Michael L. Mathai; Deanne H. Hryciw; Andrew J. McAinch

doi:10.1016/j.orcp.2018.11.168

The effect of atypical cannabinoid compounds on skeletal muscle homeostasis in a diet induced obese rat model

Anna C. Simcocks, Lannie O'Keefe, Kayte A. Jenkin, Michael L. Mathai, Deanne H. Hryciw, Andrew J. McAinch

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

Bariatric surgery remains the only effective treatment for morbid obesity. Vertical sleeve gastrectomy (VSG) is the most widely performed of the bariatric surgeries, largely because it confers not only significant weight loss but improved glucose regulation. We have recently demonstrated that brown adipose tissue (BAT) temperature and UCP1 protein expression in BAT are elevated following VSG and contribute substantially to weight loss. However, the importance of BAT in the mediation of improved glucose regulation following VSG is unclear.

Original language	English
Pages (from-to)	294-294
Number of pages	1
Journal	Obesity Research and Clinical Practice
Volume	13
Issue number	3
DOIs	https://doi.org/10.1016/j.orcp.2018.11.168
Publication status	Published - 2019

Keywords

cannabinoids
energy
homeostasis
musculoskeletal system
obesity
rats
surgery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.orcp.2018.11.168

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title = "The effect of atypical cannabinoid compounds on skeletal muscle homeostasis in a diet induced obese rat model",

abstract = "Bariatric surgery remains the only effective treatment for morbid obesity. Vertical sleeve gastrectomy (VSG) is the most widely performed of the bariatric surgeries, largely because it confers not only significant weight loss but improved glucose regulation. We have recently demonstrated that brown adipose tissue (BAT) temperature and UCP1 protein expression in BAT are elevated following VSG and contribute substantially to weight loss. However, the importance of BAT in the mediation of improved glucose regulation following VSG is unclear.",

keywords = "cannabinoids, energy, homeostasis, musculoskeletal system, obesity, rats, surgery",

author = "Simcocks, {Anna C.} and Lannie O'Keefe and Jenkin, {Kayte A.} and Mathai, {Michael L.} and Hryciw, {Deanne H.} and McAinch, {Andrew J.}",

year = "2019",

doi = "10.1016/j.orcp.2018.11.168",

language = "English",

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T1 - The effect of atypical cannabinoid compounds on skeletal muscle homeostasis in a diet induced obese rat model

AU - Simcocks, Anna C.

AU - O'Keefe, Lannie

AU - Jenkin, Kayte A.

AU - Mathai, Michael L.

AU - Hryciw, Deanne H.

AU - McAinch, Andrew J.

PY - 2019

Y1 - 2019

N2 - Bariatric surgery remains the only effective treatment for morbid obesity. Vertical sleeve gastrectomy (VSG) is the most widely performed of the bariatric surgeries, largely because it confers not only significant weight loss but improved glucose regulation. We have recently demonstrated that brown adipose tissue (BAT) temperature and UCP1 protein expression in BAT are elevated following VSG and contribute substantially to weight loss. However, the importance of BAT in the mediation of improved glucose regulation following VSG is unclear.

AB - Bariatric surgery remains the only effective treatment for morbid obesity. Vertical sleeve gastrectomy (VSG) is the most widely performed of the bariatric surgeries, largely because it confers not only significant weight loss but improved glucose regulation. We have recently demonstrated that brown adipose tissue (BAT) temperature and UCP1 protein expression in BAT are elevated following VSG and contribute substantially to weight loss. However, the importance of BAT in the mediation of improved glucose regulation following VSG is unclear.

KW - cannabinoids

KW - energy

KW - homeostasis

KW - musculoskeletal system

KW - obesity

KW - rats

KW - surgery

UR - https://hdl.handle.net/1959.7/uws:54439

U2 - 10.1016/j.orcp.2018.11.168

DO - 10.1016/j.orcp.2018.11.168

M3 - Article

SN - 1871-403X

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SP - 294

EP - 294

JO - Obesity Research and Clinical Practice

JF - Obesity Research and Clinical Practice

IS - 3

ER -

The effect of atypical cannabinoid compounds on skeletal muscle homeostasis in a diet induced obese rat model

Abstract

Keywords

UN SDGs

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