The effect of weak bases on lysosomal enzyme secretion by mononuclear phagocytes

Wendy Jessup; Patricia Leoni; Judith L. Bodmer; Roger T. Dean

doi:10.1016/0006-2952(82)90714-6

The effect of weak bases on lysosomal enzyme secretion by mononuclear phagocytes

Wendy Jessup, Patricia Leoni, Judith L. Bodmer, Roger T. Dean

Brunel University London

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

NH₄Cl induces a dose-dependent secretion of lysosomal enzymes by mouse peritoneal macrophages and human peripheral blood monocytes. The mechanism of NH₄Cl-stimulated hexosaminidase release is distinct from that initiated by the inflammatory stimulus, zymosan. The spontaneous lysosomal secretion of the continuous murine macrophage-like cell line, P388D₁, is inhibited by up to 50% in the presence of NH₄Cl and other weak bases.

Original language	English
Pages (from-to)	2657-2662
Number of pages	6
Journal	Biochemical Pharmacology
Volume	31
Issue number	16
DOIs	https://doi.org/10.1016/0006-2952(82)90714-6
Publication status	Published - 15 Aug 1982
Externally published	Yes

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10.1016/0006-2952(82)90714-6

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title = "The effect of weak bases on lysosomal enzyme secretion by mononuclear phagocytes",

abstract = "NH4Cl induces a dose-dependent secretion of lysosomal enzymes by mouse peritoneal macrophages and human peripheral blood monocytes. The mechanism of NH4Cl-stimulated hexosaminidase release is distinct from that initiated by the inflammatory stimulus, zymosan. The spontaneous lysosomal secretion of the continuous murine macrophage-like cell line, P388D1, is inhibited by up to 50% in the presence of NH4Cl and other weak bases.",

author = "Wendy Jessup and Patricia Leoni and Bodmer, {Judith L.} and Dean, {Roger T.}",

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AU - Jessup, Wendy

AU - Leoni, Patricia

AU - Bodmer, Judith L.

AU - Dean, Roger T.

PY - 1982/8/15

Y1 - 1982/8/15

N2 - NH4Cl induces a dose-dependent secretion of lysosomal enzymes by mouse peritoneal macrophages and human peripheral blood monocytes. The mechanism of NH4Cl-stimulated hexosaminidase release is distinct from that initiated by the inflammatory stimulus, zymosan. The spontaneous lysosomal secretion of the continuous murine macrophage-like cell line, P388D1, is inhibited by up to 50% in the presence of NH4Cl and other weak bases.

AB - NH4Cl induces a dose-dependent secretion of lysosomal enzymes by mouse peritoneal macrophages and human peripheral blood monocytes. The mechanism of NH4Cl-stimulated hexosaminidase release is distinct from that initiated by the inflammatory stimulus, zymosan. The spontaneous lysosomal secretion of the continuous murine macrophage-like cell line, P388D1, is inhibited by up to 50% in the presence of NH4Cl and other weak bases.

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DO - 10.1016/0006-2952(82)90714-6

M3 - Article

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AN - SCOPUS:0019959503

SN - 0006-2952

VL - 31

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JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

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ER -

The effect of weak bases on lysosomal enzyme secretion by mononuclear phagocytes

Abstract

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