The global distribution and environmental drivers of the soil antibiotic resistome

Manuel Delgado-Baquerizo; H. W. Hu; F. T. Maestre; C. A. Guerra; N. Eisenhauer; D. J. Eldridge; Y. G. Zhu; Q. L. Chen; P. Trivedi; S. Du; T. P. Makhalanyane; J. P. Verma; B. Gozalo; V. Ochoa; S. Asensio; L. Wang; E. Zaady; J. G. Illan; C. Siebe; T. Grebenc; X. Zhou; Y. R. Liu; A. R. Bamigboye; J. L. Blanco-Pastor; J. Duran; A. Rodríguez; S. Mamet; F. Alfaro; S. Abades; A. L. Teixido; G. F. Penaloza-Bojaca; M. A. Molina-Montenegro; C. Torres-Díaz; C. Perez; A. Gallardo; L. Garcia-Velazquez; P. E. Hayes; S. Neuhauser; J. Z. He

doi:10.1186/s40168‑022‑01405‑w

The global distribution and environmental drivers of the soil antibiotic resistome

Manuel Delgado-Baquerizo, H. W. Hu, F. T. Maestre, C. A. Guerra, N. Eisenhauer, D. J. Eldridge, Y. G. Zhu, Q. L. Chen, P. Trivedi, S. Du, T. P. Makhalanyane, J. P. Verma, B. Gozalo, V. Ochoa, S. Asensio, L. Wang, E. Zaady, J. G. Illan, C. Siebe, T. GrebencX. Zhou, Y. R. Liu, A. R. Bamigboye, J. L. Blanco-Pastor, J. Duran, A. Rodríguez, S. Mamet, F. Alfaro, S. Abades, A. L. Teixido, G. F. Penaloza-Bojaca, M. A. Molina-Montenegro, C. Torres-Díaz, C. Perez, A. Gallardo, L. Garcia-Velazquez, P. E. Hayes, S. Neuhauser, J. Z. He

Western Sydney University

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.

Original language	English
Article number	219
Number of pages	14
Journal	Microbiome
Volume	10
Issue number	1
DOIs	https://doi.org/10.1186/s40168‑022‑01405‑w
Publication status	Published - 2022

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Â© The Author(s) 2022. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article�s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article�s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.

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Delgado-Baquerizo, M., Hu, H. W., Maestre, F. T., Guerra, C. A., Eisenhauer, N., Eldridge, D. J., Zhu, Y. G., Chen, Q. L., Trivedi, P., Du, S., Makhalanyane, T. P., Verma, J. P., Gozalo, B., Ochoa, V., Asensio, S., Wang, L., Zaady, E., Illan, J. G., Siebe, C., ... He, J. Z. (2022). The global distribution and environmental drivers of the soil antibiotic resistome. Microbiome, 10(1), Article 219. https://doi.org/10.1186/s40168‑022‑01405‑w

@article{dd43648069bd4920875fa94a3d579ec0,

title = "The global distribution and environmental drivers of the soil antibiotic resistome",

abstract = "Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth{\textquoteright}s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.",

author = "Manuel Delgado-Baquerizo and Hu, {H. W.} and Maestre, {F. T.} and Guerra, {C. A.} and N. Eisenhauer and Eldridge, {D. J.} and Zhu, {Y. G.} and Chen, {Q. L.} and P. Trivedi and S. Du and Makhalanyane, {T. P.} and Verma, {J. P.} and B. Gozalo and V. Ochoa and S. Asensio and L. Wang and E. Zaady and Illan, {J. G.} and C. Siebe and T. Grebenc and X. Zhou and Liu, {Y. R.} and Bamigboye, {A. R.} and Blanco-Pastor, {J. L.} and J. Duran and A. Rodr{\'i}guez and S. Mamet and F. Alfaro and S. Abades and Teixido, {A. L.} and Penaloza-Bojaca, {G. F.} and Molina-Montenegro, {M. A.} and C. Torres-D{\'i}az and C. Perez and A. Gallardo and L. Garcia-Velazquez and Hayes, {P. E.} and S. Neuhauser and He, {J. Z.}",

year = "2022",

doi = "10.1186/s40168‑022‑01405‑w",

language = "English",

volume = "10",

journal = "Microbiome",

issn = "2049-2618",

publisher = "BioMed Central Ltd.",

number = "1",

}

Delgado-Baquerizo, M, Hu, HW, Maestre, FT, Guerra, CA, Eisenhauer, N, Eldridge, DJ, Zhu, YG, Chen, QL, Trivedi, P, Du, S, Makhalanyane, TP, Verma, JP, Gozalo, B, Ochoa, V, Asensio, S, Wang, L, Zaady, E, Illan, JG, Siebe, C, Grebenc, T, Zhou, X, Liu, YR, Bamigboye, AR, Blanco-Pastor, JL, Duran, J, Rodríguez, A, Mamet, S, Alfaro, F, Abades, S, Teixido, AL, Penaloza-Bojaca, GF, Molina-Montenegro, MA, Torres-Díaz, C, Perez, C, Gallardo, A, Garcia-Velazquez, L, Hayes, PE, Neuhauser, S & He, JZ 2022, 'The global distribution and environmental drivers of the soil antibiotic resistome', Microbiome, vol. 10, no. 1, 219. https://doi.org/10.1186/s40168‑022‑01405‑w

TY - JOUR

T1 - The global distribution and environmental drivers of the soil antibiotic resistome

AU - Delgado-Baquerizo, Manuel

AU - Hu, H. W.

AU - Maestre, F. T.

AU - Guerra, C. A.

AU - Eisenhauer, N.

AU - Eldridge, D. J.

AU - Zhu, Y. G.

AU - Chen, Q. L.

AU - Trivedi, P.

AU - Du, S.

AU - Makhalanyane, T. P.

AU - Verma, J. P.

AU - Gozalo, B.

AU - Ochoa, V.

AU - Asensio, S.

AU - Wang, L.

AU - Zaady, E.

AU - Illan, J. G.

AU - Siebe, C.

AU - Grebenc, T.

AU - Zhou, X.

AU - Liu, Y. R.

AU - Bamigboye, A. R.

AU - Blanco-Pastor, J. L.

AU - Duran, J.

AU - Rodríguez, A.

AU - Mamet, S.

AU - Alfaro, F.

AU - Abades, S.

AU - Teixido, A. L.

AU - Penaloza-Bojaca, G. F.

AU - Molina-Montenegro, M. A.

AU - Torres-Díaz, C.

AU - Perez, C.

AU - Gallardo, A.

AU - Garcia-Velazquez, L.

AU - Hayes, P. E.

AU - Neuhauser, S.

AU - He, J. Z.

PY - 2022

Y1 - 2022

N2 - Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.

AB - Background: Little is known about the global distribution and environmental drivers of key microbial functional traits such as antibiotic resistance genes (ARGs). Soils are one of Earth’s largest reservoirs of ARGs, which are integral for soil microbial competition, and have potential implications for plant and human health. Yet, their diversity and global patterns remain poorly described. Here, we analyzed 285 ARGs in soils from 1012 sites across all continents and created the first global atlas with the distributions of topsoil ARGs. Results: We show that ARGs peaked in high latitude cold and boreal forests. Climatic seasonality and mobile genetic elements, associated with the transmission of antibiotic resistance, were also key drivers of their global distribution. Dominant ARGs were mainly related to multidrug resistance genes and efflux pump machineries. We further pinpointed the global hotspots of the diversity and proportions of soil ARGs. Conclusions: Together, our work provides the foundation for a better understanding of the ecology and global distribution of the environmental soil antibiotic resistome.

UR - https://hdl.handle.net/1959.7/uws:76535

U2 - 10.1186/s40168‑022‑01405‑w

DO - 10.1186/s40168‑022‑01405‑w

M3 - Article

SN - 2049-2618

VL - 10

JO - Microbiome

JF - Microbiome

IS - 1

M1 - 219

ER -

The global distribution and environmental drivers of the soil antibiotic resistome

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