TY - JOUR
T1 - The impact of food availability on tumorigenesis is evolutionarily conserved
AU - Tissot, Sophie
AU - Guimard, Lena
AU - Meliani, Jordan
AU - Boutry, Justine
AU - Dujon, Antoine M.
AU - Capp, Jean-Pascal
AU - Tökölyi, Jácint
AU - Biro, Peter A.
AU - Beckmann, Christa
AU - Fontenille, Laura
AU - Do Khoa, Nam
AU - Hamede, Rodrigo
AU - Roche, Benjamin
AU - Ujvari, Beata
AU - Nedelcu, Aurora M.
AU - Thomas, Frédéric
PY - 2023/12
Y1 - 2023/12
N2 - The inability to control cell proliferation results in the formation of tumors in many multicellular lineages. Nonetheless, little is known about the extent of conservation of the biological traits and ecological factors that promote or inhibit tumorigenesis across the metazoan tree. Particularly, changes in food availability have been linked to increased cancer incidence in humans, as an outcome of evolutionary mismatch. Here, we apply evolutionary oncology principles to test whether food availability, regardless of the multicellular lineage considered, has an impact on tumorigenesis. We used two phylogenetically unrelated model systems, the cnidarian Hydra oligactis and the fish Danio rerio, to investigate the impact of resource availability on tumor occurrence and progression. Individuals from healthy and tumor-prone lines were placed on four diets that differed in feeding frequency and quantity. For both models, frequent overfeeding favored tumor emergence, while lean diets appeared more protective. In terms of tumor progression, high food availability promoted it, whereas low resources controlled it, but without having a curative effect. We discuss our results in light of current ideas about the possible conservation of basic processes governing cancer in metazoans (including ancestral life history trade-offs at the cell level) and in the framework of evolutionary medicine.
AB - The inability to control cell proliferation results in the formation of tumors in many multicellular lineages. Nonetheless, little is known about the extent of conservation of the biological traits and ecological factors that promote or inhibit tumorigenesis across the metazoan tree. Particularly, changes in food availability have been linked to increased cancer incidence in humans, as an outcome of evolutionary mismatch. Here, we apply evolutionary oncology principles to test whether food availability, regardless of the multicellular lineage considered, has an impact on tumorigenesis. We used two phylogenetically unrelated model systems, the cnidarian Hydra oligactis and the fish Danio rerio, to investigate the impact of resource availability on tumor occurrence and progression. Individuals from healthy and tumor-prone lines were placed on four diets that differed in feeding frequency and quantity. For both models, frequent overfeeding favored tumor emergence, while lean diets appeared more protective. In terms of tumor progression, high food availability promoted it, whereas low resources controlled it, but without having a curative effect. We discuss our results in light of current ideas about the possible conservation of basic processes governing cancer in metazoans (including ancestral life history trade-offs at the cell level) and in the framework of evolutionary medicine.
UR - https://hdl.handle.net/1959.7/uws:75030
UR - http://www.scopus.com/inward/record.url?scp=85176427014&partnerID=8YFLogxK
U2 - 10.1038/s41598-023-46896-1
DO - 10.1038/s41598-023-46896-1
M3 - Article
C2 - 37963956
SN - 2045-2322
VL - 13
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 19825
ER -