TY - JOUR
T1 - The impact of incomplete revascularization on early and late outcomes in ST-elevation myocardial infarction
AU - Burgess, Sonya N.
AU - French, John K.
AU - Nguyen, Tuan L.
AU - Leung, Melissa
AU - Richards, David A. B.
AU - Thomas, Liza
AU - Mussap, Christian
AU - Lo, Sidney
AU - Juergens, Craig P.
PY - 2018
Y1 - 2018
N2 - Background: In ST-elevation myocardial infarction (STEMI) in patients with multivessel disease, there is a lack of consensus regarding the importance of complete revascularization and the timing of treatment of nonculprit stenoses. Our objective was to investigate the impact of incomplete revascularization in STEMI patients using the residual Synergy Between PCI with TAXUS and Cardiac Surgery score (rSS) to define completeness of revascularization. Methods: This study examined associations between incomplete revascularization, determined by the rSS, and the combined outcome of cardiac death and myocardial infarction (MI). Patients were divided into groups: rSS = 0 (complete revascularization), rSS = 1-8 (incomplete revascularization with a low burden of residual disease), or rSS >8 (incomplete revascularization with a high burden of residual disease). Results: The rSS score was calculated in 589 consecutive patients; 25% had an rSS of 0, 42% rSS 1-8, and 33% rSS >8. At median follow-up of 3.5 years, cardiac death and MI occurred in 5% of rSS = 0 patients, 15% rSS = 1-8, and 26% with rSS >8 (P <.001). The rSS was powerful independent predictor of cardiac death and MI (hazard ratio 5.05, CI 2.89-12.00, rSS >8 vs rSS 0, P <.001 and hazard ratio 2.96, CI 1.31-6.69, rSS = 1-8 vs rSS = 0, P =.009), respectively, and an independent predictor of mortality, MI, unplanned revascularization, and major adverse cardiovascular events. Conclusions: In patients with STEMI, the rSS independently predicts cardiac death and MI. Patients with an rSS >8 had substantially higher rates of cardiac death or MI. The rSS can be used to define incomplete revascularization in STEMI and predict adverse outcomes.
AB - Background: In ST-elevation myocardial infarction (STEMI) in patients with multivessel disease, there is a lack of consensus regarding the importance of complete revascularization and the timing of treatment of nonculprit stenoses. Our objective was to investigate the impact of incomplete revascularization in STEMI patients using the residual Synergy Between PCI with TAXUS and Cardiac Surgery score (rSS) to define completeness of revascularization. Methods: This study examined associations between incomplete revascularization, determined by the rSS, and the combined outcome of cardiac death and myocardial infarction (MI). Patients were divided into groups: rSS = 0 (complete revascularization), rSS = 1-8 (incomplete revascularization with a low burden of residual disease), or rSS >8 (incomplete revascularization with a high burden of residual disease). Results: The rSS score was calculated in 589 consecutive patients; 25% had an rSS of 0, 42% rSS 1-8, and 33% rSS >8. At median follow-up of 3.5 years, cardiac death and MI occurred in 5% of rSS = 0 patients, 15% rSS = 1-8, and 26% with rSS >8 (P <.001). The rSS was powerful independent predictor of cardiac death and MI (hazard ratio 5.05, CI 2.89-12.00, rSS >8 vs rSS 0, P <.001 and hazard ratio 2.96, CI 1.31-6.69, rSS = 1-8 vs rSS = 0, P =.009), respectively, and an independent predictor of mortality, MI, unplanned revascularization, and major adverse cardiovascular events. Conclusions: In patients with STEMI, the rSS independently predicts cardiac death and MI. Patients with an rSS >8 had substantially higher rates of cardiac death or MI. The rSS can be used to define incomplete revascularization in STEMI and predict adverse outcomes.
UR - https://hdl.handle.net/1959.7/uws:64157
U2 - 10.1016/j.ahj.2018.07.017
DO - 10.1016/j.ahj.2018.07.017
M3 - Article
SN - 0002-8703
VL - 205
SP - 31
EP - 41
JO - American Heart Journal
JF - American Heart Journal
ER -