The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Junxuan Peng; Zuchao Cai; Ruixue Zhao; Jiahao Chen; Guochao Liu; Chao Dong; David Lim; Zhihui Feng

doi:10.1093/toxres/tfaa069

The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Junxuan Peng, Zuchao Cai, Ruixue Zhao, Jiahao Chen, Guochao Liu, Chao Dong, David Lim, Zhihui Feng

Western Sydney University

Research output: Contribution to journal › Article › peer-review

Abstract

This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inf lammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

Original language	English
Pages (from-to)	609-621
Number of pages	13
Journal	Toxicology Research
Volume	9
Issue number	5
DOIs	https://doi.org/10.1093/toxres/tfaa069
Publication status	Published - 2020

Keywords

breast
polycyclic aromatic hydrocarbons
tumors
valproic acid

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/toxres/tfaa069

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title = "The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs",

abstract = "This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inf lammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.",

keywords = "breast, polycyclic aromatic hydrocarbons, tumors, valproic acid",

author = "Junxuan Peng and Zuchao Cai and Ruixue Zhao and Jiahao Chen and Guochao Liu and Chao Dong and David Lim and Zhihui Feng",

year = "2020",

doi = "10.1093/toxres/tfaa069",

language = "English",

volume = "9",

pages = "609--621",

journal = "Toxicology Research",

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TY - JOUR

T1 - The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

AU - Peng, Junxuan

AU - Cai, Zuchao

AU - Zhao, Ruixue

AU - Chen, Jiahao

AU - Liu, Guochao

AU - Dong, Chao

AU - Lim, David

AU - Feng, Zhihui

PY - 2020

Y1 - 2020

N2 - This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inf lammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

AB - This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inf lammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.

KW - breast

KW - polycyclic aromatic hydrocarbons

KW - tumors

KW - valproic acid

UR - http://hdl.handle.net/1959.7/uws:57294

U2 - 10.1093/toxres/tfaa069

DO - 10.1093/toxres/tfaa069

M3 - Article

SN - 2045-452X

VL - 9

SP - 609

EP - 621

JO - Toxicology Research

JF - Toxicology Research

IS - 5

ER -

The intervention of valproic acid on the tumorigenesis induced by an environmental carcinogen of PAHs

Abstract

Keywords

UN SDGs

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