Abstract
This study investigated whether valproic acid (VPA, a histone deacetylase inhibitor) can interfere with the carcinogenicity of polycyclic aromatic hydrocarbons (PAHs). A typical representative compound of PAHs, 7,12-Dimethylbenz[a]anthracene (DMBA), was used to induce rat breast cancer. The results showed that therapeutic concentration of VPA (50 and 100 mg/kg) delayed the occurrence of tumors, reduced tumor formation rate and attenuated tumors growth, and have a protective effect on normal tissues. The macrophage-mediated inf lammatory response was found to be associated with the observed effect of VPA. In addition, we screened and validated a possible gene, Sema3c, which was involved in DMBA-induced breast cancer development and can be inhibited by VPA.
| Original language | English |
|---|---|
| Pages (from-to) | 609-621 |
| Number of pages | 13 |
| Journal | Toxicology Research |
| Volume | 9 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2020 |
Bibliographical note
Publisher Copyright:© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: [email protected]
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- breast
- polycyclic aromatic hydrocarbons
- tumors
- valproic acid
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