The multiple potential biomarkers for predicting immunotherapy response : finding the needle in the haystack

Tamiem Adam; Therese M. Becker; Wei Chua; Victoria Bray; Tara L. Roberts

doi:10.3390/cancers13020277

The multiple potential biomarkers for predicting immunotherapy response : finding the needle in the haystack

Tamiem Adam
, Therese M. Becker
, Wei Chua
, Victoria Bray
, Tara L. Roberts

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Immune checkpoint inhibitors (ICIs) are being increasingly utilised in a variety of advanced malignancies. Despite promising outcomes in certain patients, the majority will not derive benefit and are at risk of potentially serious immune-related adverse events (irAEs). The development of predictive biomarkers is therefore critical to personalise treatments and improve outcomes. A number of biomarkers have shown promising results, including from tumour (programmed cell death ligand 1 (PD-L1), tumour mutational burden (TMB), stimulator of interferon genes (STING) and apoptosis-associated speck-like protein containing a CARD (ASC)), from blood (peripheral blood mononuclear cells (PBMCs), circulating tumour DNA (ctDNA), exosomes, cytokines and metal chelators) and finally the microbiome.

Original language	English
Article number	277
Pages (from-to)	1-20
Number of pages	20
Journal	Cancers
Volume	13
Issue number	2
DOIs	https://doi.org/10.3390/cancers13020277
Publication status	Published - 2 Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors.

Open Access - Access Right Statement

© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

biochemical markers
cancer
immunotherapy
melanoma
renal cell carcinoma

Access to Document

10.3390/cancers13020277

Cite this

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abstract = "Immune checkpoint inhibitors (ICIs) are being increasingly utilised in a variety of advanced malignancies. Despite promising outcomes in certain patients, the majority will not derive benefit and are at risk of potentially serious immune-related adverse events (irAEs). The development of predictive biomarkers is therefore critical to personalise treatments and improve outcomes. A number of biomarkers have shown promising results, including from tumour (programmed cell death ligand 1 (PD-L1), tumour mutational burden (TMB), stimulator of interferon genes (STING) and apoptosis-associated speck-like protein containing a CARD (ASC)), from blood (peripheral blood mononuclear cells (PBMCs), circulating tumour DNA (ctDNA), exosomes, cytokines and metal chelators) and finally the microbiome.",

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doi = "10.3390/cancers13020277",

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T1 - The multiple potential biomarkers for predicting immunotherapy response : finding the needle in the haystack

AU - Adam, Tamiem

AU - Becker, Therese M.

AU - Chua, Wei

AU - Bray, Victoria

AU - Roberts, Tara L.

PY - 2021/1/2

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N2 - Immune checkpoint inhibitors (ICIs) are being increasingly utilised in a variety of advanced malignancies. Despite promising outcomes in certain patients, the majority will not derive benefit and are at risk of potentially serious immune-related adverse events (irAEs). The development of predictive biomarkers is therefore critical to personalise treatments and improve outcomes. A number of biomarkers have shown promising results, including from tumour (programmed cell death ligand 1 (PD-L1), tumour mutational burden (TMB), stimulator of interferon genes (STING) and apoptosis-associated speck-like protein containing a CARD (ASC)), from blood (peripheral blood mononuclear cells (PBMCs), circulating tumour DNA (ctDNA), exosomes, cytokines and metal chelators) and finally the microbiome.

AB - Immune checkpoint inhibitors (ICIs) are being increasingly utilised in a variety of advanced malignancies. Despite promising outcomes in certain patients, the majority will not derive benefit and are at risk of potentially serious immune-related adverse events (irAEs). The development of predictive biomarkers is therefore critical to personalise treatments and improve outcomes. A number of biomarkers have shown promising results, including from tumour (programmed cell death ligand 1 (PD-L1), tumour mutational burden (TMB), stimulator of interferon genes (STING) and apoptosis-associated speck-like protein containing a CARD (ASC)), from blood (peripheral blood mononuclear cells (PBMCs), circulating tumour DNA (ctDNA), exosomes, cytokines and metal chelators) and finally the microbiome.

KW - biochemical markers

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KW - immunotherapy

KW - melanoma

KW - renal cell carcinoma

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M3 - Article

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JO - Cancers

JF - Cancers

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ER -

The multiple potential biomarkers for predicting immunotherapy response : finding the needle in the haystack

Abstract

Bibliographical note

Open Access - Access Right Statement

UN SDGs

Keywords

Access to Document

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