The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

R.C. Reiner; Simon I. Hay; C.A. Welgan; C.E. Troeger; M.M. Baumann; D.J. Weiss; A. Deshpande; B.F. Blacker; M.K. Miller-Petrie; L. Earl; S. Bhatt; H. Abolhassani; A.E. Abosetugn; E. Abu-Gharbieh; V. Adekanmbi; O.O. Adetokunboh; M. Aghaali; B. Aji; F. Alahdab; Z. Al-Aly; R.K. Alhassan; S. Ali; H. Alizade; S.M. Aljunid; A. Almasi-Hashiani; H.M. Al-Mekhlafi; K.A. Altirkawi; N. Alvis-Guzman; A.T. Amare; S. Amini; D.A. Amugsi; R. Ancuceanu; C.L. Andrei; F. Ansari; D. Anvari; S.C.Y. Appiah; J. Arabloo; O. Aremu; M.M.W. Atout; M. Ausloos; F. Ausloos; M.A. Ayanore; Y.A. Aynalem; Z.N. Azene; A. Badawi; A.A. Baig; M. Banach; N. Bedi; A.S. Bhagavathula; D. Bhandari; N. Bhardwaj; P. Bhardwaj; K. Bhattacharyya; Z.A. Bhutta; A. Bijani; T.T.M. Birhanu; Z.W. Bitew; A. Boloor; O.J. Brady; Z.A. Butt; J. Car; F. Carvalho; D.C. Casey; V.K. Chattu; M.A.K. Chowdhury; D.-T. Chu; C.H. Coelho; A.J. Cook; G. Damiani; F. Daoud; J.D. Gela; A.H. Darwish; A. Daryani; J.K. Das; Weaver Davis; K. Deribe; A. Desalew; S.D. Dharmaratne; M. Dianatinasab; D. Diaz; S. Djalalinia; F. Dorostkar; E. Dubljanin; B. Duko; L. Dwyer-Lindgren; A. Effiong; Sayed El; Tantawi El; S. Enany; N. Fattahi; V.L. Feigin; E. Fernandes; P. Ferrara; F. Fischer; N.A. Foigt; M.O. Folayan; M. Foroutan; J.J. Frostad; T. Fukumoto; A.M. Gaidhane; H.G.G.K. Gebrekrstos; L. Gebremeskel; A.A. Gebreslassie; P.W. Gething; K.E. Gezae; K. Ghadiri; A. Ghashghaee; M. Golechha; M.I.M. Gubari; F.B. Hadgu; S. Hamidi; D.W. Handiso; A. Hashi; S. Hassan; K. Hayat; C. Herteliu; H.C. Ho; R. Holla; M. Hosseinzadeh; M. Househ; R. Hussain; B.-F. Hwang; S.E. Ibitoye; O.S. Ilesanmi; I.M. Ilic; M.D. Ilic; S.S.N. Irvani; J. Jaafari; T. Javaheri; R.P. Jha; K.B. Johnson; J.B. Jonas; J.J. Jozwiak; A. Kabir; R. Kalhor; T. Kanchan; A. Karch; G.A. Kayode; P.N. Keiyoro; Y.S. Khader; I.A. Khalil; M.N. Khan; M. Khan; G. Khan; K. Khatab; M.M. Khater; M.N. Khatib; N. Kianipour; Y.J. Kim; R.W. Kimokoti; S. Kisa; A. Kisa; N. Kissoon; S. Kochhar; A. Koolivand; J.A. Kopec; A. Koyanagi; K. Krishan; P. Kumar; O.P. Kurmi; D. Kusuma; D.K. Lal; F.H. Lami; I. Landires; V.C. Lansingh; S. Lasrado; Vecchia La; A. Lazzar-Atwood; P.H. Lee; K.E. LeGrand; S. Lewycka; B. Li; S.S. Lim; P.A. Lindstedt; X. Liu; J. Longbottom; A.D. Lopez; Abd Magdy; P.W. Mahasha; A. Maleki; A.A. Mamun; M.A. Mansournia; L.B. Marczak; F.R. Martins-Melo; B.K. Mayala; B.G. Meharie; A. Melese; W. Mendoza; R.G. Menezes; E.W. Mengesha; G.A. Mensah; T.J. Meretoja; T. Mestrovic; T.R. Miller; E.M. Mirrakhimov; B. Moazen; Gholi Mohammad; S. Mohammadi; S. Mohammed; A.H. Mokdad; M. Moradi; R. Moradzadeh; P. Moraga; J.F. Mosser; C.J.L. Murray; M. Naderi; A.J. Nagarajan; J. Nazari; R. Ndejjo; I. Negoi; J.W. Ngunjiri; Q.A.P. Nguyen; H.L.T. Nguyen; C.A. Nnaji; J.J. Noubiap; V. Nuñez-Samudio; A.T. Olagunju; J.O. Olusanya; B.O. Olusanya; M.O. Omer; O.E. Onwujekwe; N. Otstavnov; S.S. Otstavnov; M.O. Owolabi; A P; J.R. Padubidri; A. Pana; E.K. Peprah; H.Q. Pham; D.M. Pigott; M. Pirestani; M.J. Postma; F.H. Pottoo; H. Pourjafar; Syed Quazi; F. Rahim; V. Rahimi-Movaghar; M.H.U. Rahman; S.J. Rao; P.C. Rao; P. Rathi; S. Rawaf; D.L. Rawaf; L. Rawal; R. Rawassizadeh; L.D. Regassa; Andre M. N. Renzaho; N. Rezaei; M.S. Rezai; A.I. Ribeiro; J. Rickard; C.M. Rios-González; S.F. Rumisha; S. Sabour; S.M. Sajadi; J.A. Salomon; Kafil Samadi; A.M. Samy; J. Sanabria; B. Sartorius; D. Saxena; L.E. Schaeffer; S. Senthilkumaran; F. Sha; A.A. Shaheen; M.A. Shaikh; R. Sharma; A. Sheikh; K. Shibuya; M. Shigematsu; Shin Il; B. Simonetti; J.A. Singh; D.L. Smith; A. Soheili; A. Sokhan; E.E. Spurlock; C.T. Sreeramareddy; M.B. Sufiyan; S.J. Swartz; D.B. Tadesse; A.T. Tamiru; Y.G. Tefera; M.-H. Temsah; Z.T. Tessema; M.V. Titova; B.X. Tran; P.N. Truong; B. Unnikrishnan; E. Upadhyay; T.J. Vasankari; Y. Vasseghian; F.S. Violante; G.T. Vu; Y. Waheed; R.G. Wamai; E.G. Wassie; F.T. Welay; N.D. Wickramasinghe; K.E. Wiens; T. Wijeratne; C.S. Wiysonge; T.G. Wondmeneh; T. Yamada; S. Yaya; Y.G. Yeshitila; P. Yip; N. Yonemoto; C. Yu; D. Yuce; H. Yusefzadeh; Z. Zaidi; M. Zamanian; A. Zangeneh; Z.-J. Zhang; Y. Zhang; A. Ziapour

doi:10.1038/s41467-022-34240-6

The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

R.C. Reiner, Simon I. Hay, C.A. Welgan, C.E. Troeger, M.M. Baumann, D.J. Weiss, A. Deshpande, B.F. Blacker, M.K. Miller-Petrie, L. Earl, S. Bhatt, H. Abolhassani, A.E. Abosetugn, E. Abu-Gharbieh, V. Adekanmbi, O.O. Adetokunboh, M. Aghaali, B. Aji, F. Alahdab, Z. Al-AlyR.K. Alhassan, S. Ali, H. Alizade, S.M. Aljunid, A. Almasi-Hashiani, H.M. Al-Mekhlafi, K.A. Altirkawi, N. Alvis-Guzman, A.T. Amare, S. Amini, D.A. Amugsi, R. Ancuceanu, C.L. Andrei, F. Ansari, D. Anvari, S.C.Y. Appiah, J. Arabloo, O. Aremu, M.M.W. Atout, M. Ausloos, F. Ausloos, M.A. Ayanore, Y.A. Aynalem, Z.N. Azene, A. Badawi, A.A. Baig, M. Banach, N. Bedi, A.S. Bhagavathula, D. Bhandari, N. Bhardwaj, P. Bhardwaj, K. Bhattacharyya, Z.A. Bhutta, A. Bijani, T.T.M. Birhanu, Z.W. Bitew, A. Boloor, O.J. Brady, Z.A. Butt, J. Car, F. Carvalho, D.C. Casey, V.K. Chattu, M.A.K. Chowdhury, D.-T. Chu, C.H. Coelho, A.J. Cook, G. Damiani, F. Daoud, J.D. Gela, A.H. Darwish, A. Daryani, J.K. Das, Weaver Davis, K. Deribe, A. Desalew, S.D. Dharmaratne, M. Dianatinasab, D. Diaz, S. Djalalinia, F. Dorostkar, E. Dubljanin, B. Duko, L. Dwyer-Lindgren, A. Effiong, Sayed El, Tantawi El, S. Enany, N. Fattahi, V.L. Feigin, E. Fernandes, P. Ferrara, F. Fischer, N.A. Foigt, M.O. Folayan, M. Foroutan, J.J. Frostad, T. Fukumoto, A.M. Gaidhane, H.G.G.K. Gebrekrstos, L. Gebremeskel, A.A. Gebreslassie, P.W. Gething, K.E. Gezae, K. Ghadiri, A. Ghashghaee, M. Golechha, M.I.M. Gubari, F.B. Hadgu, S. Hamidi, D.W. Handiso, A. Hashi, S. Hassan, K. Hayat, C. Herteliu, H.C. Ho, R. Holla, M. Hosseinzadeh, M. Househ, R. Hussain, B.-F. Hwang, S.E. Ibitoye, O.S. Ilesanmi, I.M. Ilic, M.D. Ilic, S.S.N. Irvani, J. Jaafari, T. Javaheri, R.P. Jha, K.B. Johnson, J.B. Jonas, J.J. Jozwiak, A. Kabir, R. Kalhor, T. Kanchan, A. Karch, G.A. Kayode, P.N. Keiyoro, Y.S. Khader, I.A. Khalil, M.N. Khan, M. Khan, G. Khan, K. Khatab, M.M. Khater, M.N. Khatib, N. Kianipour, Y.J. Kim, R.W. Kimokoti, S. Kisa, A. Kisa, N. Kissoon, S. Kochhar, A. Koolivand, J.A. Kopec, A. Koyanagi, K. Krishan, P. Kumar, O.P. Kurmi, D. Kusuma, D.K. Lal, F.H. Lami, I. Landires, V.C. Lansingh, S. Lasrado, Vecchia La, A. Lazzar-Atwood, P.H. Lee, K.E. LeGrand, S. Lewycka, B. Li, S.S. Lim, P.A. Lindstedt, X. Liu, J. Longbottom, A.D. Lopez, Abd Magdy, P.W. Mahasha, A. Maleki, A.A. Mamun, M.A. Mansournia, L.B. Marczak, F.R. Martins-Melo, B.K. Mayala, B.G. Meharie, A. Melese, W. Mendoza, R.G. Menezes, E.W. Mengesha, G.A. Mensah, T.J. Meretoja, T. Mestrovic, T.R. Miller, E.M. Mirrakhimov, B. Moazen, Gholi Mohammad, S. Mohammadi, S. Mohammed, A.H. Mokdad, M. Moradi, R. Moradzadeh, P. Moraga, J.F. Mosser, C.J.L. Murray, M. Naderi, A.J. Nagarajan, J. Nazari, R. Ndejjo, I. Negoi, J.W. Ngunjiri, Q.A.P. Nguyen, H.L.T. Nguyen, C.A. Nnaji, J.J. Noubiap, V. Nuñez-Samudio, A.T. Olagunju, J.O. Olusanya, B.O. Olusanya, M.O. Omer, O.E. Onwujekwe, N. Otstavnov, S.S. Otstavnov, M.O. Owolabi, A P, J.R. Padubidri, A. Pana, E.K. Peprah, H.Q. Pham, D.M. Pigott, M. Pirestani, M.J. Postma, F.H. Pottoo, H. Pourjafar, Syed Quazi, F. Rahim, V. Rahimi-Movaghar, M.H.U. Rahman, S.J. Rao, P.C. Rao, P. Rathi, S. Rawaf, D.L. Rawaf, L. Rawal, R. Rawassizadeh, L.D. Regassa, Andre M. N. Renzaho, N. Rezaei, M.S. Rezai, A.I. Ribeiro, J. Rickard, C.M. Rios-González, S.F. Rumisha, S. Sabour, S.M. Sajadi, J.A. Salomon, Kafil Samadi, A.M. Samy, J. Sanabria, B. Sartorius, D. Saxena, L.E. Schaeffer, S. Senthilkumaran, F. Sha, A.A. Shaheen, M.A. Shaikh, R. Sharma, A. Sheikh, K. Shibuya, M. Shigematsu, Shin Il, B. Simonetti, J.A. Singh, D.L. Smith, A. Soheili, A. Sokhan, E.E. Spurlock, C.T. Sreeramareddy, M.B. Sufiyan, S.J. Swartz, D.B. Tadesse, A.T. Tamiru, Y.G. Tefera, M.-H. Temsah, Z.T. Tessema, M.V. Titova, B.X. Tran, P.N. Truong, B. Unnikrishnan, E. Upadhyay, T.J. Vasankari, Y. Vasseghian, F.S. Violante, G.T. Vu, Y. Waheed, R.G. Wamai, E.G. Wassie, F.T. Welay, N.D. Wickramasinghe, K.E. Wiens, T. Wijeratne, C.S. Wiysonge, T.G. Wondmeneh, T. Yamada, S. Yaya, Y.G. Yeshitila, P. Yip, N. Yonemoto, C. Yu, D. Yuce, H. Yusefzadeh, Z. Zaidi, M. Zamanian, A. Zangeneh, Z.-J. Zhang, Y. Zhang, A. Ziapour

Western Sydney University

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

Original language	English
Article number	7457
Number of pages	14
Journal	Nature Communications
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/s41467-022-34240-6
Publication status	Published - 2022

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/s41467-022-34240-6

Cite this

Reiner, R. C., Hay, S. I., Welgan, C. A., Troeger, C. E., Baumann, M. M., Weiss, D. J., Deshpande, A., Blacker, B. F., Miller-Petrie, M. K., Earl, L., Bhatt, S., Abolhassani, H., Abosetugn, A. E., Abu-Gharbieh, E., Adekanmbi, V., Adetokunboh, O. O., Aghaali, M., Aji, B., Alahdab, F., ... Ziapour, A. (2022). The overlapping burden of the three leading causes of disability and death in sub-Saharan African children. Nature Communications, 13(1), Article 7457. https://doi.org/10.1038/s41467-022-34240-6

@article{44177c3761b04921a7f42a54a3f6fcbd,

title = "The overlapping burden of the three leading causes of disability and death in sub-Saharan African children",

abstract = "Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.",

author = "R.C. Reiner and Hay, {Simon I.} and C.A. Welgan and C.E. Troeger and M.M. Baumann and D.J. Weiss and A. Deshpande and B.F. Blacker and M.K. Miller-Petrie and L. Earl and S. Bhatt and H. Abolhassani and A.E. Abosetugn and E. Abu-Gharbieh and V. Adekanmbi and O.O. Adetokunboh and M. Aghaali and B. Aji and F. Alahdab and Z. Al-Aly and R.K. Alhassan and S. Ali and H. Alizade and S.M. Aljunid and A. Almasi-Hashiani and H.M. Al-Mekhlafi and K.A. Altirkawi and N. Alvis-Guzman and A.T. Amare and S. Amini and D.A. Amugsi and R. Ancuceanu and C.L. Andrei and F. Ansari and D. Anvari and S.C.Y. Appiah and J. Arabloo and O. Aremu and M.M.W. Atout and M. Ausloos and F. Ausloos and M.A. Ayanore and Y.A. Aynalem and Z.N. Azene and A. Badawi and A.A. Baig and M. Banach and N. Bedi and A.S. Bhagavathula and D. Bhandari and N. Bhardwaj and P. Bhardwaj and K. Bhattacharyya and Z.A. Bhutta and A. Bijani and T.T.M. Birhanu and Z.W. Bitew and A. Boloor and O.J. Brady and Z.A. Butt and J. Car and F. Carvalho and D.C. Casey and V.K. Chattu and M.A.K. Chowdhury and D.-T. Chu and C.H. Coelho and A.J. Cook and G. Damiani and F. Daoud and J.D. Gela and A.H. Darwish and A. Daryani and J.K. Das and Weaver Davis and K. Deribe and A. Desalew and S.D. Dharmaratne and M. Dianatinasab and D. Diaz and S. Djalalinia and F. Dorostkar and E. Dubljanin and B. Duko and L. Dwyer-Lindgren and A. Effiong and Sayed El and Tantawi El and S. Enany and N. Fattahi and V.L. Feigin and E. Fernandes and P. Ferrara and F. Fischer and N.A. Foigt and M.O. Folayan and M. Foroutan and J.J. Frostad and T. Fukumoto and A.M. Gaidhane and H.G.G.K. Gebrekrstos and L. Gebremeskel and A.A. Gebreslassie and P.W. Gething and K.E. Gezae and K. Ghadiri and A. Ghashghaee and M. Golechha and M.I.M. Gubari and F.B. Hadgu and S. Hamidi and D.W. Handiso and A. Hashi and S. Hassan and K. Hayat and C. Herteliu and H.C. Ho and R. Holla and M. Hosseinzadeh and M. Househ and R. Hussain and B.-F. Hwang and S.E. Ibitoye and O.S. Ilesanmi and I.M. Ilic and M.D. Ilic and S.S.N. Irvani and J. Jaafari and T. Javaheri and R.P. Jha and K.B. Johnson and J.B. Jonas and J.J. Jozwiak and A. Kabir and R. Kalhor and T. Kanchan and A. Karch and G.A. Kayode and P.N. Keiyoro and Y.S. Khader and I.A. Khalil and M.N. Khan and M. Khan and G. Khan and K. Khatab and M.M. Khater and M.N. Khatib and N. Kianipour and Y.J. Kim and R.W. Kimokoti and S. Kisa and A. Kisa and N. Kissoon and S. Kochhar and A. Koolivand and J.A. Kopec and A. Koyanagi and K. Krishan and P. Kumar and O.P. Kurmi and D. Kusuma and D.K. Lal and F.H. Lami and I. Landires and V.C. Lansingh and S. Lasrado and Vecchia La and A. Lazzar-Atwood and P.H. Lee and K.E. LeGrand and S. Lewycka and B. Li and S.S. Lim and P.A. Lindstedt and X. Liu and J. Longbottom and A.D. Lopez and Abd Magdy and P.W. Mahasha and A. Maleki and A.A. Mamun and M.A. Mansournia and L.B. Marczak and F.R. Martins-Melo and B.K. Mayala and B.G. Meharie and A. Melese and W. Mendoza and R.G. Menezes and E.W. Mengesha and G.A. Mensah and T.J. Meretoja and T. Mestrovic and T.R. Miller and E.M. Mirrakhimov and B. Moazen and Gholi Mohammad and S. Mohammadi and S. Mohammed and A.H. Mokdad and M. Moradi and R. Moradzadeh and P. Moraga and J.F. Mosser and C.J.L. Murray and M. Naderi and A.J. Nagarajan and J. Nazari and R. Ndejjo and I. Negoi and J.W. Ngunjiri and Q.A.P. Nguyen and H.L.T. Nguyen and C.A. Nnaji and J.J. Noubiap and V. Nu{\~n}ez-Samudio and A.T. Olagunju and J.O. Olusanya and B.O. Olusanya and M.O. Omer and O.E. Onwujekwe and N. Otstavnov and S.S. Otstavnov and M.O. Owolabi and A P and J.R. Padubidri and A. Pana and E.K. Peprah and H.Q. Pham and D.M. Pigott and M. Pirestani and M.J. Postma and F.H. Pottoo and H. Pourjafar and Syed Quazi and F. Rahim and V. Rahimi-Movaghar and M.H.U. Rahman and S.J. Rao and P.C. Rao and P. Rathi and S. Rawaf and D.L. Rawaf and L. Rawal and R. Rawassizadeh and L.D. Regassa and Renzaho, {Andre M. N.} and N. Rezaei and M.S. Rezai and A.I. Ribeiro and J. Rickard and C.M. Rios-Gonz{\'a}lez and S.F. Rumisha and S. Sabour and S.M. Sajadi and J.A. Salomon and Kafil Samadi and A.M. Samy and J. Sanabria and B. Sartorius and D. Saxena and L.E. Schaeffer and S. Senthilkumaran and F. Sha and A.A. Shaheen and M.A. Shaikh and R. Sharma and A. Sheikh and K. Shibuya and M. Shigematsu and Shin Il and B. Simonetti and J.A. Singh and D.L. Smith and A. Soheili and A. Sokhan and E.E. Spurlock and C.T. Sreeramareddy and M.B. Sufiyan and S.J. Swartz and D.B. Tadesse and A.T. Tamiru and Y.G. Tefera and M.-H. Temsah and Z.T. Tessema and M.V. Titova and B.X. Tran and P.N. Truong and B. Unnikrishnan and E. Upadhyay and T.J. Vasankari and Y. Vasseghian and F.S. Violante and G.T. Vu and Y. Waheed and R.G. Wamai and E.G. Wassie and F.T. Welay and N.D. Wickramasinghe and K.E. Wiens and T. Wijeratne and C.S. Wiysonge and T.G. Wondmeneh and T. Yamada and S. Yaya and Y.G. Yeshitila and P. Yip and N. Yonemoto and C. Yu and D. Yuce and H. Yusefzadeh and Z. Zaidi and M. Zamanian and A. Zangeneh and Z.-J. Zhang and Y. Zhang and A. Ziapour",

year = "2022",

doi = "10.1038/s41467-022-34240-6",

language = "English",

volume = "13",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

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Reiner, RC, Hay, SI, Welgan, CA, Troeger, CE, Baumann, MM, Weiss, DJ, Deshpande, A, Blacker, BF, Miller-Petrie, MK, Earl, L, Bhatt, S, Abolhassani, H, Abosetugn, AE, Abu-Gharbieh, E, Adekanmbi, V, Adetokunboh, OO, Aghaali, M, Aji, B, Alahdab, F, Al-Aly, Z, Alhassan, RK, Ali, S, Alizade, H, Aljunid, SM, Almasi-Hashiani, A, Al-Mekhlafi, HM, Altirkawi, KA, Alvis-Guzman, N, Amare, AT, Amini, S, Amugsi, DA, Ancuceanu, R, Andrei, CL, Ansari, F, Anvari, D, Appiah, SCY, Arabloo, J, Aremu, O, Atout, MMW, Ausloos, M, Ausloos, F, Ayanore, MA, Aynalem, YA, Azene, ZN, Badawi, A, Baig, AA, Banach, M, Bedi, N, Bhagavathula, AS, Bhandari, D, Bhardwaj, N, Bhardwaj, P, Bhattacharyya, K, Bhutta, ZA, Bijani, A, Birhanu, TTM, Bitew, ZW, Boloor, A, Brady, OJ, Butt, ZA, Car, J, Carvalho, F, Casey, DC, Chattu, VK, Chowdhury, MAK, Chu, D-T, Coelho, CH, Cook, AJ, Damiani, G, Daoud, F, Gela, JD, Darwish, AH, Daryani, A, Das, JK, Davis, W, Deribe, K, Desalew, A, Dharmaratne, SD, Dianatinasab, M, Diaz, D, Djalalinia, S, Dorostkar, F, Dubljanin, E, Duko, B, Dwyer-Lindgren, L, Effiong, A, El, S, El, T, Enany, S, Fattahi, N, Feigin, VL, Fernandes, E, Ferrara, P, Fischer, F, Foigt, NA, Folayan, MO, Foroutan, M, Frostad, JJ, Fukumoto, T, Gaidhane, AM, Gebrekrstos, HGGK, Gebremeskel, L, Gebreslassie, AA, Gething, PW, Gezae, KE, Ghadiri, K, Ghashghaee, A, Golechha, M, Gubari, MIM, Hadgu, FB, Hamidi, S, Handiso, DW, Hashi, A, Hassan, S, Hayat, K, Herteliu, C, Ho, HC, Holla, R, Hosseinzadeh, M, Househ, M, Hussain, R, Hwang, B-F, Ibitoye, SE, Ilesanmi, OS, Ilic, IM, Ilic, MD, Irvani, SSN, Jaafari, J, Javaheri, T, Jha, RP, Johnson, KB, Jonas, JB, Jozwiak, JJ, Kabir, A, Kalhor, R, Kanchan, T, Karch, A, Kayode, GA, Keiyoro, PN, Khader, YS, Khalil, IA, Khan, MN, Khan, M, Khan, G, Khatab, K, Khater, MM, Khatib, MN, Kianipour, N, Kim, YJ, Kimokoti, RW, Kisa, S, Kisa, A, Kissoon, N, Kochhar, S, Koolivand, A, Kopec, JA, Koyanagi, A, Krishan, K, Kumar, P, Kurmi, OP, Kusuma, D, Lal, DK, Lami, FH, Landires, I, Lansingh, VC, Lasrado, S, La, V, Lazzar-Atwood, A, Lee, PH, LeGrand, KE, Lewycka, S, Li, B, Lim, SS, Lindstedt, PA, Liu, X, Longbottom, J, Lopez, AD, Magdy, A, Mahasha, PW, Maleki, A, Mamun, AA, Mansournia, MA, Marczak, LB, Martins-Melo, FR, Mayala, BK, Meharie, BG, Melese, A, Mendoza, W, Menezes, RG, Mengesha, EW, Mensah, GA, Meretoja, TJ, Mestrovic, T, Miller, TR, Mirrakhimov, EM, Moazen, B, Mohammad, G, Mohammadi, S, Mohammed, S, Mokdad, AH, Moradi, M, Moradzadeh, R, Moraga, P, Mosser, JF, Murray, CJL, Naderi, M, Nagarajan, AJ, Nazari, J, Ndejjo, R, Negoi, I, Ngunjiri, JW, Nguyen, QAP, Nguyen, HLT, Nnaji, CA, Noubiap, JJ, Nuñez-Samudio, V, Olagunju, AT, Olusanya, JO, Olusanya, BO, Omer, MO, Onwujekwe, OE, Otstavnov, N, Otstavnov, SS, Owolabi, MO, P, A, Padubidri, JR, Pana, A, Peprah, EK, Pham, HQ, Pigott, DM, Pirestani, M, Postma, MJ, Pottoo, FH, Pourjafar, H, Quazi, S, Rahim, F, Rahimi-Movaghar, V, Rahman, MHU, Rao, SJ, Rao, PC, Rathi, P, Rawaf, S, Rawaf, DL, Rawal, L, Rawassizadeh, R, Regassa, LD, Renzaho, AMN, Rezaei, N, Rezai, MS, Ribeiro, AI, Rickard, J, Rios-González, CM, Rumisha, SF, Sabour, S, Sajadi, SM, Salomon, JA, Samadi, K, Samy, AM, Sanabria, J, Sartorius, B, Saxena, D, Schaeffer, LE, Senthilkumaran, S, Sha, F, Shaheen, AA, Shaikh, MA, Sharma, R, Sheikh, A, Shibuya, K, Shigematsu, M, Il, S, Simonetti, B, Singh, JA, Smith, DL, Soheili, A, Sokhan, A, Spurlock, EE, Sreeramareddy, CT, Sufiyan, MB, Swartz, SJ, Tadesse, DB, Tamiru, AT, Tefera, YG, Temsah, M-H, Tessema, ZT, Titova, MV, Tran, BX, Truong, PN, Unnikrishnan, B, Upadhyay, E, Vasankari, TJ, Vasseghian, Y, Violante, FS, Vu, GT, Waheed, Y, Wamai, RG, Wassie, EG, Welay, FT, Wickramasinghe, ND, Wiens, KE, Wijeratne, T, Wiysonge, CS, Wondmeneh, TG, Yamada, T, Yaya, S, Yeshitila, YG, Yip, P, Yonemoto, N, Yu, C, Yuce, D, Yusefzadeh, H, Zaidi, Z, Zamanian, M, Zangeneh, A, Zhang, Z-J, Zhang, Y & Ziapour, A 2022, 'The overlapping burden of the three leading causes of disability and death in sub-Saharan African children', Nature Communications, vol. 13, no. 1, 7457. https://doi.org/10.1038/s41467-022-34240-6

TY - JOUR

T1 - The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

AU - Reiner, R.C.

AU - Hay, Simon I.

AU - Welgan, C.A.

AU - Troeger, C.E.

AU - Baumann, M.M.

AU - Weiss, D.J.

AU - Deshpande, A.

AU - Blacker, B.F.

AU - Miller-Petrie, M.K.

AU - Earl, L.

AU - Bhatt, S.

AU - Abolhassani, H.

AU - Abosetugn, A.E.

AU - Abu-Gharbieh, E.

AU - Adekanmbi, V.

AU - Adetokunboh, O.O.

AU - Aghaali, M.

AU - Aji, B.

AU - Alahdab, F.

AU - Al-Aly, Z.

AU - Alhassan, R.K.

AU - Ali, S.

AU - Alizade, H.

AU - Aljunid, S.M.

AU - Almasi-Hashiani, A.

AU - Al-Mekhlafi, H.M.

AU - Altirkawi, K.A.

AU - Alvis-Guzman, N.

AU - Amare, A.T.

AU - Amini, S.

AU - Amugsi, D.A.

AU - Ancuceanu, R.

AU - Andrei, C.L.

AU - Ansari, F.

AU - Anvari, D.

AU - Appiah, S.C.Y.

AU - Arabloo, J.

AU - Aremu, O.

AU - Atout, M.M.W.

AU - Ausloos, M.

AU - Ausloos, F.

AU - Ayanore, M.A.

AU - Aynalem, Y.A.

AU - Azene, Z.N.

AU - Badawi, A.

AU - Baig, A.A.

AU - Banach, M.

AU - Bedi, N.

AU - Bhagavathula, A.S.

AU - Bhandari, D.

AU - Bhardwaj, N.

AU - Bhardwaj, P.

AU - Bhattacharyya, K.

AU - Bhutta, Z.A.

AU - Bijani, A.

AU - Birhanu, T.T.M.

AU - Bitew, Z.W.

AU - Boloor, A.

AU - Brady, O.J.

AU - Butt, Z.A.

AU - Car, J.

AU - Carvalho, F.

AU - Casey, D.C.

AU - Chattu, V.K.

AU - Chowdhury, M.A.K.

AU - Chu, D.-T.

AU - Coelho, C.H.

AU - Cook, A.J.

AU - Damiani, G.

AU - Daoud, F.

AU - Gela, J.D.

AU - Darwish, A.H.

AU - Daryani, A.

AU - Das, J.K.

AU - Davis, Weaver

AU - Deribe, K.

AU - Desalew, A.

AU - Dharmaratne, S.D.

AU - Dianatinasab, M.

AU - Diaz, D.

AU - Djalalinia, S.

AU - Dorostkar, F.

AU - Dubljanin, E.

AU - Duko, B.

AU - Dwyer-Lindgren, L.

AU - Effiong, A.

AU - El, Sayed

AU - El, Tantawi

AU - Enany, S.

AU - Fattahi, N.

AU - Feigin, V.L.

AU - Fernandes, E.

AU - Ferrara, P.

AU - Fischer, F.

AU - Foigt, N.A.

AU - Folayan, M.O.

AU - Foroutan, M.

AU - Frostad, J.J.

AU - Fukumoto, T.

AU - Gaidhane, A.M.

AU - Gebrekrstos, H.G.G.K.

AU - Gebremeskel, L.

AU - Gebreslassie, A.A.

AU - Gething, P.W.

AU - Gezae, K.E.

AU - Ghadiri, K.

AU - Ghashghaee, A.

AU - Golechha, M.

AU - Gubari, M.I.M.

AU - Hadgu, F.B.

AU - Hamidi, S.

AU - Handiso, D.W.

AU - Hashi, A.

AU - Hassan, S.

AU - Hayat, K.

AU - Herteliu, C.

AU - Ho, H.C.

AU - Holla, R.

AU - Hosseinzadeh, M.

AU - Househ, M.

AU - Hussain, R.

AU - Hwang, B.-F.

AU - Ibitoye, S.E.

AU - Ilesanmi, O.S.

AU - Ilic, I.M.

AU - Ilic, M.D.

AU - Irvani, S.S.N.

AU - Jaafari, J.

AU - Javaheri, T.

AU - Jha, R.P.

AU - Johnson, K.B.

AU - Jonas, J.B.

AU - Jozwiak, J.J.

AU - Kabir, A.

AU - Kalhor, R.

AU - Kanchan, T.

AU - Karch, A.

AU - Kayode, G.A.

AU - Keiyoro, P.N.

AU - Khader, Y.S.

AU - Khalil, I.A.

AU - Khan, M.N.

AU - Khan, M.

AU - Khan, G.

AU - Khatab, K.

AU - Khater, M.M.

AU - Khatib, M.N.

AU - Kianipour, N.

AU - Kim, Y.J.

AU - Kimokoti, R.W.

AU - Kisa, S.

AU - Kisa, A.

AU - Kissoon, N.

AU - Kochhar, S.

AU - Koolivand, A.

AU - Kopec, J.A.

AU - Koyanagi, A.

AU - Krishan, K.

AU - Kumar, P.

AU - Kurmi, O.P.

AU - Kusuma, D.

AU - Lal, D.K.

AU - Lami, F.H.

AU - Landires, I.

AU - Lansingh, V.C.

AU - Lasrado, S.

AU - La, Vecchia

AU - Lazzar-Atwood, A.

AU - Lee, P.H.

AU - LeGrand, K.E.

AU - Lewycka, S.

AU - Li, B.

AU - Lim, S.S.

AU - Lindstedt, P.A.

AU - Liu, X.

AU - Longbottom, J.

AU - Lopez, A.D.

AU - Magdy, Abd

AU - Mahasha, P.W.

AU - Maleki, A.

AU - Mamun, A.A.

AU - Mansournia, M.A.

AU - Marczak, L.B.

AU - Martins-Melo, F.R.

AU - Mayala, B.K.

AU - Meharie, B.G.

AU - Melese, A.

AU - Mendoza, W.

AU - Menezes, R.G.

AU - Mengesha, E.W.

AU - Mensah, G.A.

AU - Meretoja, T.J.

AU - Mestrovic, T.

AU - Miller, T.R.

AU - Mirrakhimov, E.M.

AU - Moazen, B.

AU - Mohammad, Gholi

AU - Mohammadi, S.

AU - Mohammed, S.

AU - Mokdad, A.H.

AU - Moradi, M.

AU - Moradzadeh, R.

AU - Moraga, P.

AU - Mosser, J.F.

AU - Murray, C.J.L.

AU - Naderi, M.

AU - Nagarajan, A.J.

AU - Nazari, J.

AU - Ndejjo, R.

AU - Negoi, I.

AU - Ngunjiri, J.W.

AU - Nguyen, Q.A.P.

AU - Nguyen, H.L.T.

AU - Nnaji, C.A.

AU - Noubiap, J.J.

AU - Nuñez-Samudio, V.

AU - Olagunju, A.T.

AU - Olusanya, J.O.

AU - Olusanya, B.O.

AU - Omer, M.O.

AU - Onwujekwe, O.E.

AU - Otstavnov, N.

AU - Otstavnov, S.S.

AU - Owolabi, M.O.

AU - P, A

AU - Padubidri, J.R.

AU - Pana, A.

AU - Peprah, E.K.

AU - Pham, H.Q.

AU - Pigott, D.M.

AU - Pirestani, M.

AU - Postma, M.J.

AU - Pottoo, F.H.

AU - Pourjafar, H.

AU - Quazi, Syed

AU - Rahim, F.

AU - Rahimi-Movaghar, V.

AU - Rahman, M.H.U.

AU - Rao, S.J.

AU - Rao, P.C.

AU - Rathi, P.

AU - Rawaf, S.

AU - Rawaf, D.L.

AU - Rawal, L.

AU - Rawassizadeh, R.

AU - Regassa, L.D.

AU - Renzaho, Andre M. N.

AU - Rezaei, N.

AU - Rezai, M.S.

AU - Ribeiro, A.I.

AU - Rickard, J.

AU - Rios-González, C.M.

AU - Rumisha, S.F.

AU - Sabour, S.

AU - Sajadi, S.M.

AU - Salomon, J.A.

AU - Samadi, Kafil

AU - Samy, A.M.

AU - Sanabria, J.

AU - Sartorius, B.

AU - Saxena, D.

AU - Schaeffer, L.E.

AU - Senthilkumaran, S.

AU - Sha, F.

AU - Shaheen, A.A.

AU - Shaikh, M.A.

AU - Sharma, R.

AU - Sheikh, A.

AU - Shibuya, K.

AU - Shigematsu, M.

AU - Il, Shin

AU - Simonetti, B.

AU - Singh, J.A.

AU - Smith, D.L.

AU - Soheili, A.

AU - Sokhan, A.

AU - Spurlock, E.E.

AU - Sreeramareddy, C.T.

AU - Sufiyan, M.B.

AU - Swartz, S.J.

AU - Tadesse, D.B.

AU - Tamiru, A.T.

AU - Tefera, Y.G.

AU - Temsah, M.-H.

AU - Tessema, Z.T.

AU - Titova, M.V.

AU - Tran, B.X.

AU - Truong, P.N.

AU - Unnikrishnan, B.

AU - Upadhyay, E.

AU - Vasankari, T.J.

AU - Vasseghian, Y.

AU - Violante, F.S.

AU - Vu, G.T.

AU - Waheed, Y.

AU - Wamai, R.G.

AU - Wassie, E.G.

AU - Welay, F.T.

AU - Wickramasinghe, N.D.

AU - Wiens, K.E.

AU - Wijeratne, T.

AU - Wiysonge, C.S.

AU - Wondmeneh, T.G.

AU - Yamada, T.

AU - Yaya, S.

AU - Yeshitila, Y.G.

AU - Yip, P.

AU - Yonemoto, N.

AU - Yu, C.

AU - Yuce, D.

AU - Yusefzadeh, H.

AU - Zaidi, Z.

AU - Zamanian, M.

AU - Zangeneh, A.

AU - Zhang, Z.-J.

AU - Zhang, Y.

AU - Ziapour, A.

PY - 2022

Y1 - 2022

N2 - Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

AB - Despite substantial declines since 2000, lower respiratory infections (LRIs), diarrhoeal diseases, and malaria remain among the leading causes of nonfatal and fatal disease burden for children under 5 years of age (under 5), primarily in sub-Saharan Africa (SSA). The spatial burden of each of these diseases has been estimated subnationally across SSA, yet no prior analyses have examined the pattern of their combined burden. Here we synthesise subnational estimates of the burden of LRIs, diarrhoea, and malaria in children under-5 from 2000 to 2017 for 43 sub-Saharan countries. Some units faced a relatively equal burden from each of the three diseases, while others had one or two dominant sources of unit-level burden, with no consistent pattern geographically across the entire subcontinent. Using a subnational counterfactual analysis, we show that nearly 300 million DALYs could have been averted since 2000 by raising all units to their national average. Our findings are directly relevant for decision-makers in determining which and targeting where the most appropriate interventions are for increasing child survival.

UR - https://hdl.handle.net/1959.7/uws:77984

U2 - 10.1038/s41467-022-34240-6

DO - 10.1038/s41467-022-34240-6

M3 - Article

SN - 2041-1723

VL - 13

JO - Nature Communications

JF - Nature Communications

IS - 1

M1 - 7457

ER -

The overlapping burden of the three leading causes of disability and death in sub-Saharan African children

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UN SDGs

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