The performance of second generation silica monoliths, operating in parallel segmented flow mode

Arianne Soliven; Dominic Foley; Luisa Pereira; Sercan Pravadali-Cekic; Gary R. Dennis; Karin Cabrera; Harald Ritchie; Tony Edge; R. Andrew Shalliker

doi:10.1016/j.microc.2015.08.022

The performance of second generation silica monoliths, operating in parallel segmented flow mode

Arianne Soliven, Dominic Foley, Luisa Pereira, Sercan Pravadali-Cekic, Gary R. Dennis, Karin Cabrera, Harald Ritchie, Tony Edge, R. Andrew Shalliker

School of Science

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

This study investigates the chromatographic performance of second generation monoliths in its conventional design, as well as replacing the standard outlet with an Active Flow Technology (AFT) assembly to minimise inefficient flow contributions. The AFT coupled monolith resulted in up to 50% improvement on the conventional monolith's efficiency and a 16% improvement in sensitivity. Exploitation of the current second generation monolith's silica infrastructure and AFT coupling in the parallel segmented flow (PSF) mode of operation would benefit high through-put analyses that demand highly efficient, sensitive, low volume detection, front end separation solutions utilizing conventional HPLC systems.

Original language	English
Pages (from-to)	657-661
Number of pages	5
Journal	Microchemical Journal
Volume	124
DOIs	https://doi.org/10.1016/j.microc.2015.08.022
Publication status	Published - 1 Jan 2016

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

active flow technology
high performance liquid chromatography
performance
silica monoliths

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10.1016/j.microc.2015.08.022

Cite this

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title = "The performance of second generation silica monoliths, operating in parallel segmented flow mode",

abstract = "This study investigates the chromatographic performance of second generation monoliths in its conventional design, as well as replacing the standard outlet with an Active Flow Technology (AFT) assembly to minimise inefficient flow contributions. The AFT coupled monolith resulted in up to 50% improvement on the conventional monolith's efficiency and a 16% improvement in sensitivity. Exploitation of the current second generation monolith's silica infrastructure and AFT coupling in the parallel segmented flow (PSF) mode of operation would benefit high through-put analyses that demand highly efficient, sensitive, low volume detection, front end separation solutions utilizing conventional HPLC systems.",

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doi = "10.1016/j.microc.2015.08.022",

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T1 - The performance of second generation silica monoliths, operating in parallel segmented flow mode

AU - Soliven, Arianne

AU - Foley, Dominic

AU - Pereira, Luisa

AU - Pravadali-Cekic, Sercan

AU - Dennis, Gary R.

AU - Cabrera, Karin

AU - Ritchie, Harald

AU - Edge, Tony

AU - Shalliker, R. Andrew

PY - 2016/1/1

Y1 - 2016/1/1

N2 - This study investigates the chromatographic performance of second generation monoliths in its conventional design, as well as replacing the standard outlet with an Active Flow Technology (AFT) assembly to minimise inefficient flow contributions. The AFT coupled monolith resulted in up to 50% improvement on the conventional monolith's efficiency and a 16% improvement in sensitivity. Exploitation of the current second generation monolith's silica infrastructure and AFT coupling in the parallel segmented flow (PSF) mode of operation would benefit high through-put analyses that demand highly efficient, sensitive, low volume detection, front end separation solutions utilizing conventional HPLC systems.

AB - This study investigates the chromatographic performance of second generation monoliths in its conventional design, as well as replacing the standard outlet with an Active Flow Technology (AFT) assembly to minimise inefficient flow contributions. The AFT coupled monolith resulted in up to 50% improvement on the conventional monolith's efficiency and a 16% improvement in sensitivity. Exploitation of the current second generation monolith's silica infrastructure and AFT coupling in the parallel segmented flow (PSF) mode of operation would benefit high through-put analyses that demand highly efficient, sensitive, low volume detection, front end separation solutions utilizing conventional HPLC systems.

KW - active flow technology

KW - high performance liquid chromatography

KW - performance

KW - silica monoliths

UR - http://handle.uws.edu.au:8081/1959.7/uws:32857

U2 - 10.1016/j.microc.2015.08.022

DO - 10.1016/j.microc.2015.08.022

M3 - Article

SN - 0026-265X

VL - 124

SP - 657

EP - 661

JO - Microchemical Journal

JF - Microchemical Journal

ER -

The performance of second generation silica monoliths, operating in parallel segmented flow mode

Abstract

Bibliographical note

Keywords

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