Abstract
Coactosin is one of the numerous actin-binding proteins which regulate the actin cytoskeleton. Coactosin binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Coactosin and human coactosin like protein 1 (COTL1) have the potential to play a role in the degradation or impairment of neuronal cells and their functioning. Its homology to other proteins that affect neuronal cells also contributes to this notion. The objective of this review is to explore its structural novelty, regulation and its significance in neurodegenerative diseases.
| Original language | English |
|---|---|
| Article number | 107 |
| Pages (from-to) | 20-24 |
| Number of pages | 5 |
| Journal | Biochemistry and Modern Applications |
| Volume | 1 |
| Issue number | 1 |
| Publication status | Published - 2017 |
Open Access - Access Right Statement
© 2017 Myers SJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Keywords
- cytoskeleton
- degeneration
- lipoxygenases
- nervous system