The role of multi-modality imaging in the diagnosis of cardiac amyloidosis: a focused update

Shaun Khanna; Ivy Wen; Aditya Bhat; Henry H.L. Chen; Gary Gan; Faraz Pathan; Timothy C. Tan

doi:10.3389/fcvm.2020.590557

The role of multi-modality imaging in the diagnosis of cardiac amyloidosis: a focused update

Shaun Khanna, Ivy Wen, Aditya Bhat, Henry H.L. Chen, Gary Gan, Faraz Pathan, Timothy C. Tan

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Cardiac amyloidosis (CA) is a unique disease entity involving an infiltrative process, typically resulting in a restrictive cardiomyopathy with diastolic heart failure that ultimately progresses to systolic heart failure. The two most common subtypes are light-chain and transthyretin amyloidosis. Early diagnosis of this disease entity, especially light-chain CA subtype, is crucial, as it portends a poorer prognosis. This review focuses on the clinical utility of the various imaging modalities in the diagnosis and differentiation of CA subtypes. This review also aims to highlight the key advances in each of the imaging modalities in the diagnosis and prognostication of CA.

Original language	English
Article number	590557
Number of pages	11
Journal	Frontiers in Cardiovascular Medicine
Volume	7
DOIs	https://doi.org/10.3389/fcvm.2020.590557
Publication status	Published - Oct 2020
Externally published	Yes

Keywords

Cardiac amyloidosis
Cardiac MRI
CT cardiac scan
DPD scintigraphy
Global longitudinal strain
Pet scan
Speckle tracking echocardiography

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fcvm.2020.590557Licence: CC BY

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title = "The role of multi-modality imaging in the diagnosis of cardiac amyloidosis: a focused update",

abstract = "Cardiac amyloidosis (CA) is a unique disease entity involving an infiltrative process, typically resulting in a restrictive cardiomyopathy with diastolic heart failure that ultimately progresses to systolic heart failure. The two most common subtypes are light-chain and transthyretin amyloidosis. Early diagnosis of this disease entity, especially light-chain CA subtype, is crucial, as it portends a poorer prognosis. This review focuses on the clinical utility of the various imaging modalities in the diagnosis and differentiation of CA subtypes. This review also aims to highlight the key advances in each of the imaging modalities in the diagnosis and prognostication of CA.",

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AU - Khanna, Shaun

AU - Wen, Ivy

AU - Bhat, Aditya

AU - Chen, Henry H.L.

AU - Gan, Gary

AU - Pathan, Faraz

AU - Tan, Timothy C.

PY - 2020/10

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AB - Cardiac amyloidosis (CA) is a unique disease entity involving an infiltrative process, typically resulting in a restrictive cardiomyopathy with diastolic heart failure that ultimately progresses to systolic heart failure. The two most common subtypes are light-chain and transthyretin amyloidosis. Early diagnosis of this disease entity, especially light-chain CA subtype, is crucial, as it portends a poorer prognosis. This review focuses on the clinical utility of the various imaging modalities in the diagnosis and differentiation of CA subtypes. This review also aims to highlight the key advances in each of the imaging modalities in the diagnosis and prognostication of CA.

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KW - Cardiac MRI

KW - CT cardiac scan

KW - DPD scintigraphy

KW - Global longitudinal strain

KW - Pet scan

KW - Speckle tracking echocardiography

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The role of multi-modality imaging in the diagnosis of cardiac amyloidosis: a focused update

Abstract

Keywords

UN SDGs

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