The role of obesity in inflammatory bowel disease

Roxane Kreuter, Miriam Wankell, Golo Ahlenstiel, Lionel Hebbard

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

In just over a generation overweight and obesity has become a worldwide healthconcern. The ramifications for this on future health care costs and longevity are consequent, whilst increased adiposity is a harbinger for diabetes, kidney and bone failure, and cancer. An area of intense interest where the role of adiposity is avidly discussed is in inflammatory bowel disease (IBD), which presents mainly as Crohn's disease (CD) and ulcerative colitis (UC). Studies in patients associating IBD with a western diet are divergent. Nevertheless, elegant studies have found gene polymorphisms in humans that in murine models parallel the inflammatory and gut microbiome changes seen in IBD patients. However, an area not to be ignored are the alterations in adipocyte function with ensuing adiposity, in particular and a focus of this review, the dysregulation of the levels of adipocytokines such as leptinand adiponectin. Herein, we present and discuss the known influences of a western diet on IBD in patients and rodent models and how adipocytokines could influence the IBD disease process.
Original languageEnglish
Pages (from-to)63-72
Number of pages10
JournalBiochimica et Biophysica Acta. Molecular Basis of Disease
Volume1865
Issue number1
DOIs
Publication statusPublished - 2019

Keywords

  • diseases
  • inflammation
  • intestines

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