TY - JOUR
T1 - The role of obesity in inflammatory bowel disease
AU - Kreuter, Roxane
AU - Wankell, Miriam
AU - Ahlenstiel, Golo
AU - Hebbard, Lionel
PY - 2019
Y1 - 2019
N2 - In just over a generation overweight and obesity has become a worldwide healthconcern. The ramifications for this on future health care costs and longevity are consequent, whilst increased adiposity is a harbinger for diabetes, kidney and bone failure, and cancer. An area of intense interest where the role of adiposity is avidly discussed is in inflammatory bowel disease (IBD), which presents mainly as Crohn's disease (CD) and ulcerative colitis (UC). Studies in patients associating IBD with a western diet are divergent. Nevertheless, elegant studies have found gene polymorphisms in humans that in murine models parallel the inflammatory and gut microbiome changes seen in IBD patients. However, an area not to be ignored are the alterations in adipocyte function with ensuing adiposity, in particular and a focus of this review, the dysregulation of the levels of adipocytokines such as leptinand adiponectin. Herein, we present and discuss the known influences of a western diet on IBD in patients and rodent models and how adipocytokines could influence the IBD disease process.
AB - In just over a generation overweight and obesity has become a worldwide healthconcern. The ramifications for this on future health care costs and longevity are consequent, whilst increased adiposity is a harbinger for diabetes, kidney and bone failure, and cancer. An area of intense interest where the role of adiposity is avidly discussed is in inflammatory bowel disease (IBD), which presents mainly as Crohn's disease (CD) and ulcerative colitis (UC). Studies in patients associating IBD with a western diet are divergent. Nevertheless, elegant studies have found gene polymorphisms in humans that in murine models parallel the inflammatory and gut microbiome changes seen in IBD patients. However, an area not to be ignored are the alterations in adipocyte function with ensuing adiposity, in particular and a focus of this review, the dysregulation of the levels of adipocytokines such as leptinand adiponectin. Herein, we present and discuss the known influences of a western diet on IBD in patients and rodent models and how adipocytokines could influence the IBD disease process.
KW - diseases
KW - inflammation
KW - intestines
UR - http://handle.westernsydney.edu.au:8081/1959.7/uws:50287
U2 - 10.1016/j.bbadis.2018.10.020
DO - 10.1016/j.bbadis.2018.10.020
M3 - Article
SN - 0925-4439
VL - 1865
SP - 63
EP - 72
JO - Biochimica et Biophysica Acta. Molecular Basis of Disease
JF - Biochimica et Biophysica Acta. Molecular Basis of Disease
IS - 1
ER -